Background In treatment-resistant depression, commonly defined as a lack of response to
two or more consecutive treatments during the current depressive episode, the percentage …

The selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed
pharmacological treatment for depression. Since their introduction many have considered …

Background Previous studies indicate that early symptomatic improvement, typically
observed during the first 4 weeks of psychological therapy, is associated with positive …

Background Post-partum depression is a serious mood disorder in women that might be
triggered by peripartum fluctuations in reproductive hormones. This phase 2 study …

Objective: Recently, innovative statistical tools have been used to model patterns of change
in psychological treatments. These tools can detect patterns of change in patient progress …

Thiazolidinediones have shown antidepressant effect in animal studies, as well as in some
uncontrolled studies evaluating human subjects with concurrent major depressive disorder …

BACKGROUND: There is substantial evidence that early improvement (EI) under
antidepressant treatment is a clinically useful predictor of later treatment outcome in patients …

Objectives To systematically examine the effectiveness, tolerability, and safety of
brexanolone infusion in treating postpartum depression (PPD). Methods Randomized …

Studies have found that up to two-thirds of patients with major depressive disorder (MDD) do
not fully respond to the first antidepressant. While switching antidepressants is a common …

Background Major depressive disorder (MDD) is a debilitating mental illness with more than
50% of patients not achieving an adequate response using first-line treatments. Reliable …