The endothelium, a cellular monolayer lining the blood vessel wall, plays a critical role in
maintaining multiorgan health and homeostasis. Endothelial functions in health include …

Liver sinusoidal endothelial cells (LSECs) form the wall of the hepatic sinusoids. Unlike
other capillaries, they lack an organized basement membrane and have cytoplasm that is …

Diabetes mellitus (DM) is one of the most prevalent chronic diseases worldwide. High
morbidity and mortality caused by DM are closely linked to its complications in multiple …

Atherosclerosis, the chronic accumulation of cholesterol-rich plaque within arteries, is
associated with a broad spectrum of cardiovascular diseases including myocardial …

Resveratrol, the phenolic substance isolated initially from Veratrum grandiflorum and richly
present in grapes, wine, peanuts, soy, and berries, has been attracting attention of scientists …

Resveratrol induces mitochondrial biogenesis and protects against metabolic decline, but
whether SIRT1 mediates these benefits is the subject of debate. To circumvent the …

Atherosclerotic vascular disease and its complications are among the top causes of mortality
worldwide. In the vascular lumen, atherosclerotic plaques are not randomly distributed …

Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

Sirtuins catalyze NAD+-dependent protein deacetylation and are critical regulators of
transcription, apoptosis, metabolism, and aging. There are seven human sirtuins (SIRT1–7) …

Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including
transcription factors thereby regulating metabolism, stress resistance, cellular survival …