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Rational Design of l-Threonine Transaldolase-Mediated System for Enhanced Florfenicol Intermediate Production
Z **, L Li, Z Liu, X Wu, Y Xu… - Journal of Agricultural and …, 2023 - ACS Publications
l-threo-p-methylsulfonylphenylserine (compound 1b) is the main intermediate of florfenicol,
and its efficient synthesis has been the subject of current research. Herein, Burkholderia …
and its efficient synthesis has been the subject of current research. Herein, Burkholderia …
Expanding the L-threonine transaldolase toolbox for the diastereomeric synthesis of β‑hydroxy-α-amino acids
Z **, L Li, X Zhang, Z Jiang, R Zhang, Y Xu, W Zhang - Molecular Catalysis, 2023 - Elsevier
L-threonine transaldolases (LTTA) catalyze the stereoselective synthesis L-threonine and
aldehydes to β‑hydroxy-α-amino acids (βHAAs). The few sources of discovered LTTAs with …
aldehydes to β‑hydroxy-α-amino acids (βHAAs). The few sources of discovered LTTAs with …
Cofactor-dependence alteration of 7β-hydroxysteroid dehydrogenase: Enhancing one-pot synthesis efficiency of chenodeoxycholic acid to ursodeoxycholic acid …
X **e, R Huang, W Zhang, R Zhang - International Journal of Biological …, 2024 - Elsevier
Abstract NAD+-dependent 7α-hydroxysteroid dehydrogenase (7α-HSDH) and NADPH-
dependent 7β-hydroxysteroid dehydrogenase (7β-HSDH) are involved in the biosynthesis of …
dependent 7β-hydroxysteroid dehydrogenase (7β-HSDH) are involved in the biosynthesis of …
Bicyclo [3.2. 0] carbocyclic Molecules and Redox Biotransformations: The Evolution of Closed-Loop Artificial Linear Biocatalytic Cascades and Related Redox-Neutral …
A Willetts - Molecules, 2023 - mdpi.com
The role of cofactor recycling in determining the efficiency of artificial biocatalytic cascades
has become paramount in recent years. Closed-loop cofactor recycling, which initially …
has become paramount in recent years. Closed-loop cofactor recycling, which initially …
Design of St-2-2 7α-HSDH mutants for altering substrate preference and thermostability
Y Pan, S Tang, L Zhu, D Lou, J Tan, B Wang - Molecular Catalysis, 2023 - Elsevier
Tauroursodeoxycholic acid (TUDCA) is the main active ingredient in bear bile powder. 7α-
hydroxysteroid dehydrogenase (7α-HSDH), which selectively catalyzes the oxidation of …
hydroxysteroid dehydrogenase (7α-HSDH), which selectively catalyzes the oxidation of …
Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield
YK Cen, L Zhang, Y Jiang, XF Meng, Y Li… - Organic & …, 2024 - pubs.rsc.org
Catalytic activity is undoubtedly a key focus in enzyme engineering. The complicated
reaction conditions hinder some enzymes from industrialization even though they have …
reaction conditions hinder some enzymes from industrialization even though they have …
Engineering the cofactor binding site of 7α-hydroxysteroid dehydrogenase for improvement of catalytic activity, thermostability, and alteration of substrate preference
Y Pan, L Zhu, J Tan, D Lou, B Wang - International Journal of Biological …, 2024 - Elsevier
Hydroxysteroid dehydrogenases (HSDHs) are crucial for bile acid metabolism and influence
the size of the bile acid pool and gut microbiota composition. HSDHs with high activity …
the size of the bile acid pool and gut microbiota composition. HSDHs with high activity …
Semi-rational engineering of 7β-hydroxysteroid dehydrogenase enhances forward reaction activity towards ursodeoxycholic acid synthesis
X **e, R Huang, W Zhang, R Zhang - International Journal of Biological …, 2025 - Elsevier
Abstract 7β-Hydroxysteroid dehydrogenase (7β-HSDH) catalyzes the reversible reaction
between 7-ketolithocholic acid (7K-LCA) and ursodeoxycholic acid (UDCA). However, its …
between 7-ketolithocholic acid (7K-LCA) and ursodeoxycholic acid (UDCA). However, its …
Enhanced synthesis of chloramphenicol intermediate L-threo-p-nitrophenylserine using engineered L-threonine transaldolase and by-product elimination
Z **, Y Xu, Z Liu, X Zhang, Q Zhu, L Li… - International Journal of …, 2024 - Elsevier
Abstract L-threo-p-nitrophenylserine (component 2) is an important intermediate during
synthesis of chloramphenicol. However, its biosynthesis is limited by enzyme activity and …
synthesis of chloramphenicol. However, its biosynthesis is limited by enzyme activity and …
A novel NADP (H)-dependent 7alpha-HSDH: discovery and construction of substrate selectivity mutant by C-terminal truncation
Y Pan, S Tang, M Zhou, F Ao, Z Tang, L Zhu, D Lou… - Catalysts, 2022 - mdpi.com
7α-Hydroxysteroid dehydrogenase (7α-HSDH) plays an important role in the biosynthesis of
tauroursodeoxycholic acid (TUDCA) using complex substrate chicken bile powder as raw …
tauroursodeoxycholic acid (TUDCA) using complex substrate chicken bile powder as raw …