International Union of Basic and Clinical Pharmacology. CXVII: Taste 2 receptors: Structures, functions, activators and blockers
M Behrens - Pharmacological Reviews, 2024 - Elsevier
Bitter perception plays a critical role for the detection of potentially harmful substances in
food items for most vertebrates. The detection of bitter compounds is facilitated by …
food items for most vertebrates. The detection of bitter compounds is facilitated by …
Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice
M Duquenne, E Deligia, C Folgueira, C Bourouh… - Molecular …, 2024 - Elsevier
Abstract Objectives In Western society, high-caloric diets rich in fats and sugars have fueled
the obesity epidemic and its related disorders. Disruption of the body-brain communication …
the obesity epidemic and its related disorders. Disruption of the body-brain communication …
Tracheal tuft cells release ATP and link innate to adaptive immunity in pneumonia
Tracheal tuft cells shape immune responses in the airways. While some of these effects
have been attributed to differential release of either acetylcholine, leukotriene C4 and/or …
have been attributed to differential release of either acetylcholine, leukotriene C4 and/or …
Long term Coptidis Rhizoma intake induce gastrointestinal emptying inhibition and colon barrier weaken via bitter taste receptors activation in mice
Z Wu, W Yang, T Wu, Y Liu, Y Pu, W Hu, Y Jiang… - Phytomedicine, 2025 - Elsevier
Abstract Background Coptidis Rhizoma, a classic bitter traditional Chinese medicine, can
lead to digestive dysfunction when long-term use according to traditional experience. Bitter …
lead to digestive dysfunction when long-term use according to traditional experience. Bitter …
Hypothalamic neuronal-glial crosstalk in metabolic disease
LT Nguyen, GT Dodd - npj Metabolic Health and Disease, 2024 - nature.com
Metabolic diseases such as obesity and type 2 diabetes affect> 2 billion people worldwide,
yet there are currently no effective treatments to promote remission of disease. It is therefore …
yet there are currently no effective treatments to promote remission of disease. It is therefore …
[PDF][PDF] Regulating Itgb1 to Restore GnRH-Tanycyte Unit Function in PCOS-Related Hypothalamic Dysregulation
Y Wang, X Tong, Y **ao, Y Wang, W Hu, W Lu, Y Chen… - Research, 2025 - spj.science.org
Excessive gonadotropin-releasing hormone (GnRH) is considered to be an initiating factor
in the etiology of polycystic ovary syndrome (PCOS). GnRH neuronal axons terminate at the …
in the etiology of polycystic ovary syndrome (PCOS). GnRH neuronal axons terminate at the …
Insufficient TRPM5 Mediates Lipotoxicity-induced Pancreatic β-cell Dysfunction
K Wang, S Wu, Z Yao, Y Zhu, X Han - Current Medical Science, 2024 - Springer
Objective While the reduction of transient receptor potential channel subfamily M member 5
(TRPM5) has been reported in islet cells from type 2 diabetic (T2D) mouse models, its role in …
(TRPM5) has been reported in islet cells from type 2 diabetic (T2D) mouse models, its role in …
Sex-specific hypothalamic neuropathology and glucose metabolism in an amyloidosis transgenic mouse model of Alzheimer's disease
G Qi, H Tang, P Gong, Y Liu, C He, J Hu, S Kang… - Cell & Bioscience, 2024 - Springer
Background Amyloid toxicity and glucose metabolic disorders are key pathological features
during the progression of Alzheimer's disease (AD). While the hypothalamus plays a crucial …
during the progression of Alzheimer's disease (AD). While the hypothalamus plays a crucial …