Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have
decreased melanin in affected tissues and suffer from severe visual abnormalities, including …

Melanosomes are the specialized intracellular organelles of pigment cells devoted to the
synthesis, storage and transport of melanin pigments, which are responsible for most visible …

Retinal pigment epithelium (RPE) is a polarized cell layer critical for photoreceptor function
and survival. The unique physiology and relationship to the photoreceptors make the RPE a …

Our understanding of the development of the retina and visual pathways has seen
enormous advances during the past 25years. New imaging technologies, coupled with …

Albinism is a genetic defect characterized by a loss of pigmentation. The neurosensory
retina, which is not pigmented, exhibits pathologic changes secondary to the loss of …

The retinal pigment epithelium (RPE) is a highly specialised pigmented monolayer
sandwiched between the choroid and the photoreceptors in the retina. Key functions of the …

l-3, 4-Dihydroxyphenylalanine (l-DOPA) is the most effective therapeutic agent for
Parkinson's disease (PD). l-DOPA is traditionally believed to be an inert amino acid that …

In the develo** murine eye, melanin synthesis in the retinal pigment epithelium (RPE)
coincides with neurogenesis of retinal ganglion cells (RGCs). Disruption of pigmentation in …

GPCRs transform extracellular stimuli into a physiological response by activating an
intracellular signaling cascade initiated via binding to G proteins. Orphan G protein-coupled …

Neurogenesis occurs in the hippocampus throughout life and is implicated in various
physiological brain functions such as memory encoding and mood regulation. L-3, 4 …