The challenge of personalized medicine is to move away from the traditional 'one-size-fits-
all'pharmacology to genotype-based individualized therapies. As an individual's response to …

An undesirable effect associated with bisphosphonates is osteonecrosis of the jaw (ONJ).
Case reports discussed ONJ development in patients with multiple myeloma or metastatic …

Introduction: Polymorphisms of genes encoding enzymes of the mevalonate pathway could
modulate the response to amino-bisphosphonate treatment in postmenopausal …

The early genetic prediction of personal drug therapy outcome, both in terms of identification
of poor responders or nonresponders, as well as of subjects at risk of develo** adverse …

The possibility to predict the outcome of medical treatments, both in terms of efficacy and
development of adverse effects, is the main goal of modern personalized medicine. The …

Drug response is known to be highly variable among treated patients. Today is well
established that sequence variants in the human genome are one of the main causes of …

Introduction: Polymorphisms of genes encoding enzymes of the mevalonate pathway could
modulate the response to amino-bisphosphonate treatment in postmenopausal …