A student's guide to neural circuit tracing

C Saleeba, B Dempsey, S Le, A Goodchild… - Frontiers in …, 2019 - frontiersin.org
The mammalian nervous system is comprised of a seemingly infinitely complex network of
specialized synaptic connections that coordinate the flow of information through it. The field …

Insights into cerebellar development and connectivity

J Beckinghausen, RV Sillitoe - Neuroscience letters, 2019 - Elsevier
The cerebellum has a well-established role in controlling motor functions such coordination,
balance, posture, and skilled learning. There is mounting evidence that it might also play a …

Neuromodulation of the cerebellum rescues movement in a mouse model of ataxia

LN Miterko, T Lin, J Zhou, ME van der Heijden… - Nature …, 2021 - nature.com
Deep brain stimulation (DBS) relieves motor dysfunction in Parkinson's disease, and other
movement disorders. Here, we demonstrate the potential benefits of DBS in a model of …

An excitatory projection from the basal forebrain to the ventral tegmental area that underlies anorexia-like phenotypes

J Cai, Y Jiang, Y Xu, Z Jiang, C Young, H Li… - Neuron, 2024 - cell.com
Maladaptation in balancing internal energy needs and external threat cues may result in
eating disorders. However, brain mechanisms underlying such maladaptations remain …

Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a mouse model of head-and-neck cancer

J Barr, A Walz, AC Restaino, M Amit, SM Barclay… - Elife, 2024 - elifesciences.org
Cancer patients often experience changes in mental health, prompting an exploration into
whether nerves infiltrating tumors contribute to these alterations by impacting brain …

Fluorescence imaging of peripheral nerve function and structure

X Yang, Y Zhang, Y Liu, Y Wang, N Zhou - Journal of Materials …, 2023 - pubs.rsc.org
Peripheral nerve injuries are common and can cause catastrophic consequences. Although
peripheral nerves have notable regenerative capacity, full functional recovery is often …

Intra-tumoral nerve-tracing in a novel syngeneic model of high-grade serous ovarian carcinoma

JL Barr, A Kruse, AC Restaino, N Tulina… - Cells, 2021 - mdpi.com
Dense tumor innervation is associated with enhanced cancer progression and poor
prognosis. We observed innervation in breast, prostate, pancreatic, lung, liver, ovarian, and …

Retrograde tracing of breast cancer‐associated sensory neurons

S Kallogjerovic, I Velázquez‐Quesada… - Journal of …, 2024 - Wiley Online Library
Breast cancer is one of the leading causes of mortality among women. The tumour
microenvironment, consisting of host cells and extracellular matrix, has been increasingly …

“Probe, Sample, and Instrument (PSI)”: the hat-trick for fluorescence live cell imaging

L Galas, T Gallavardin, M Bénard, A Lehner… - Chemosensors, 2018 - mdpi.com
Cell Imaging Platforms (CIPs) are research infrastructures offering support to a number of
scientific projects including the choice of adapted fluorescent probes for live cell imaging …

Transneuronal tracing to map connectivity in injured and transplanted spinal networks

TA Fortino, ML Randelman, AA Hall, J Singh… - Experimental …, 2022 - Elsevier
It has become widely appreciated that the spinal cord has significant neuroplastic potential,
is not hard-wired, and that with traumatic injury and anatomical plasticity, the networks that …