[HTML][HTML] Spatially resolved transcriptomics: a comprehensive review of their technological advances, applications, and challenges
The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …
technology, from the invention of the microscope 350 years ago to the recent emergence of …
[HTML][HTML] Spatial transcriptomics: Technologies, applications and experimental considerations
The diverse cell types of an organ have a highly structured organization to enable their
efficient and correct function. To fully appreciate gene functions in a given cell type, one …
efficient and correct function. To fully appreciate gene functions in a given cell type, one …
Characteristics of blood–brain barrier heterogeneity between brain regions revealed by profiling vascular and perivascular cells
The blood–brain barrier (BBB) protects the brain and maintains neuronal homeostasis. BBB
properties can vary between brain regions to support regional functions, yet how BBB …
properties can vary between brain regions to support regional functions, yet how BBB …
An airway-to-brain sensory pathway mediates influenza-induced sickness
Pathogen infection causes a stereotyped state of sickness that involves neuronally
orchestrated behavioural and physiological changes,. On infection, immune cells release a …
orchestrated behavioural and physiological changes,. On infection, immune cells release a …
A body–brain circuit that regulates body inflammatory responses
The body-brain axis is emerging as a principal conductor of organismal physiology. It
senses and controls organ function1, 2, metabolism3 and nutritional state4-6. Here, we …
senses and controls organ function1, 2, metabolism3 and nutritional state4-6. Here, we …
The gut microbiome in disorders of gut–brain interaction
Functional gastrointestinal disorders (FGIDs), chronic disorders characterized by either
abdominal pain, altered intestinal motility, or their combination, have a worldwide …
abdominal pain, altered intestinal motility, or their combination, have a worldwide …
A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis
Orchestrating complex behaviors, such as approaching and consuming food, is critical for
survival. In addition to hypothalamus neuronal circuits, the nucleus accumbens (NAc) also …
survival. In addition to hypothalamus neuronal circuits, the nucleus accumbens (NAc) also …
SARS-CoV-2 S1 subunit produces a protracted priming of the neuroinflammatory, physiological, and behavioral responses to a remote immune challenge: A role for …
MG Frank, JB Ball, S Hopkins, T Kelley… - Brain, Behavior, and …, 2024 - Elsevier
Long COVID is a major public health consequence of COVID-19 and is characterized by
multiple neurological and neuropsychatric symptoms. SARS-CoV-2 antigens (eg, spike S1 …
multiple neurological and neuropsychatric symptoms. SARS-CoV-2 antigens (eg, spike S1 …
The parabrachial nucleus elicits a vigorous corticosterone feedback response to the pro-inflammatory cytokine IL-1β
F Jagot, R Gaston-Breton, AJ Choi, M Pascal, L Bourhy… - Neuron, 2023 - cell.com
The central nervous system regulates systemic immune responses by integrating the
physiological and behavioral constraints faced by an individual. Corticosterone (CS), the …
physiological and behavioral constraints faced by an individual. Corticosterone (CS), the …
Spatial transcriptomics in neuroscience
N Jung, TK Kim - Experimental & Molecular Medicine, 2023 - nature.com
The brain is one of the most complex living tissue types and is composed of an exceptional
diversity of cell types displaying unique functional connectivity. Single-cell RNA sequencing …
diversity of cell types displaying unique functional connectivity. Single-cell RNA sequencing …