Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

Over the past decade, organs-on-a-chip and microphysiological systems have emerged as a
disruptive in vitro technology for biopharmaceutical applications. By enabling new …

Purpose The aim of this study was to design and fabricate a three-dimensional (3D) printed
artificial ovary. Methods We first compared the printability of gelatin-methacryloyl (GelMA) …

Considerable challenges in engineering the female reproductive tissue are the follicle's
unique architecture, the need to recapitulate the extracellular matrix, and tissue …

To reduce the required capital and time investment in the development of new
pharmaceutical agents, there is an urgent need for preclinical drug testing models that are …

Nearly all cardiovascular diseases show sexual dimorphisms in prevalence, presentation,
and outcomes. Until recently, most clinical trials were carried out in males, and many animal …

Obesity and its numerous adverse health consequences have taken on global, pandemic
proportions. White adipose tissue (WAT)–a key contributor in many metabolic diseases …

Abstract Organ-on-a-chip (OOC) systems were developed by combining microfluidic
technologies and tissue engineering to mimic physiological conditions in the body. OOC …

The transgender adult population is growing globally, but clinical pharmacology has lagged
behind other areas of transgender medicine. Medical care for transgender adults may …

Recent years have seen continued expansion of the functionality of lab on a chip (LOC)
devices. Indeed LOCs now provide scientists and developers with useful and versatile …