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Redox regulation of the immune response
G Morris, M Gevezova, V Sarafian… - Cellular & Molecular …, 2022 - nature.com
The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …
Tumor abnormality-oriented nanomedicine design
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …
Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment
Tumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix
accumulation, which is associated with diminished antitumor immune infiltration. Here we …
accumulation, which is associated with diminished antitumor immune infiltration. Here we …
Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases
Y Yu, Y Yan, F Niu, Y Wang, X Chen, G Su, Y Liu… - Cell death …, 2021 - nature.com
Ferroptosis, a recently identified and iron-dependent cell death, differs from other cell death
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …
such as apoptosis, necroptosis, pyroptosis, and autophagy-dependent cell death. This form …
Engineering nanomedicine for glutathione depletion-augmented cancer therapy
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …
Functions of ROS in macrophages and antimicrobial immunity
M Herb, M Schramm - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
Selenium–GPX4 axis protects follicular helper T cells from ferroptosis
Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that essentially
support germinal center responses where high-affinity and long-lived humoral immunity is …
support germinal center responses where high-affinity and long-lived humoral immunity is …
Metabolism of immune cells in cancer
Through the successes of checkpoint blockade and adoptive cellular therapy,
immunotherapy has become an established treatment modality for cancer. Cellular …
immunotherapy has become an established treatment modality for cancer. Cellular …
The complex interplay between antioxidants and ROS in cancer
Reactive oxygen species (ROS) play important roles in tissue homeostasis, cellular
signaling, differentiation, and survival. In this review, we discuss the types of ROS, their …
signaling, differentiation, and survival. In this review, we discuss the types of ROS, their …
Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation
Age is a non-modifiable risk factor for the inflammation that underlies age-associated
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …
diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine …