The multifaceted role of ferroptosis in liver disease
Ferroptosis is an iron-dependent form of non-apoptotic cell death characterized by
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …
excessive lipid peroxidation and associated with a plethora of pathological conditions in the …
Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …
GSCA: an integrated platform for gene set cancer analysis at genomic, pharmacogenomic and immunogenomic levels
Cancer initiation and progression are likely caused by the dysregulation of biological
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …
pathways. Gene set analysis (GSA) could improve the signal-to-noise ratio and identify …
7-Dehydrocholesterol dictates ferroptosis sensitivity
Y Li, Q Ran, Q Duan, J **, Y Wang, L Yu, C Wang… - Nature, 2024 - nature.com
Ferroptosis, a form of regulated cell death that is driven by iron-dependent phospholipid
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …
peroxidation, has been implicated in multiple diseases, including cancer,–, degenerative …
[HTML][HTML] mTORC1 couples cyst (e) ine availability with GPX4 protein synthesis and ferroptosis regulation
Abstract Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid
peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 …
peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 …
Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
A Schwab, Z Rao, J Zhang, A Gollowitzer… - Nature Cell …, 2024 - nature.com
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a
(partial) activation of the epithelial–mesenchymal transition (EMT) programme. A …
(partial) activation of the epithelial–mesenchymal transition (EMT) programme. A …
Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7
Coenzyme Q (or ubiquinone) is a redox-active lipid that serves as universal electron carrier
in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid …
in the mitochondrial respiratory chain and antioxidant in the plasma membrane limiting lipid …
A targetable LIFR− NF-κB− LCN2 axis controls liver tumorigenesis and vulnerability to ferroptosis
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …
ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer …
MYCN mediates cysteine addiction and sensitizes neuroblastoma to ferroptosis
Aberrant expression of MYC transcription factor family members predicts poor clinical
outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and …
outcome in many human cancers. Oncogenic MYC profoundly alters metabolism and …
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent
peroxidation of lipids,. The glutathione-dependent lipid hydroperoxidase glutathione …
peroxidation of lipids,. The glutathione-dependent lipid hydroperoxidase glutathione …