The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary
transport gates for molecular exchange between nucleus and cytoplasm. Strip** the …

Molecular mechanistic biology has ushered us into the world of life's building blocks,
revealing their interactions in macromolecular complexes and inspiring strategies for …

Nuclear pore complexes (NPCs) provide a selective passageway for receptor-mediated
active transport between nucleus and cytoplasm, while maintaining the distinct molecular …

Internal membrane bound structures sequester all genetic material in eukaryotic cells. The
most prominent of these structures is the nucleus, which is bounded by a double membrane …

We describe a simple illumination method of fluorescence microscopy for molecular
imaging. Illumination by a highly inclined and thin beam increases image intensity and …

The spatial separation of DNA replication and gene transcription in the nucleus and protein
translation in the cytoplasm is a uniform principle of eukaryotic cells. This …

The nuclear import of proteins through nuclear pore complexes (NPCs) illustrates how a
complex biological function can be generated by a spatially and temporally organized cycle …

Ever since their introduction two decades ago, single-molecule (SM) fluorescence methods
have matured and branched out to address numerous biological questions, which were …

Multi-color fluorescent nanodiamonds (FNDs) containing a variety of color centers are
promising fluorescent markers for biomedical applications. Compared to colloidal quantum …