We update complementary learning systems (CLS) theory, which holds that intelligent
agents must possess two learning systems, instantiated in mammalians in neocortex and …

The CA3 region of the hippocampus is important for rapid encoding of memory.
Computational theories have proposed specific roles in hippocampal function and memory …

We develop further here the only quantitative theory of the storage of information in the
hippocampal episodic memory system and its recall back to the neocortex. The theory is …

The central problems that goal-directed animals must solve are:'What do I need and Why,
Where and When can this be obtained, and How do I get it?'or the H4W problem. Here, we …

To support cognitive function, the CA3 region of the hippocampus performs computations
involving attractor dynamics. Understanding how cellular and ensemble activities of CA3 …

Much has been learned about the hippocampal/entorhinal system, but an overview of how
its parts work in an integrated way is lacking. One question regards the function of entorhinal …

The widely acknowledged cognitive theory of depression, developed by Aaron Beck,
focused on biased information processing that emphasizes the negative aspects of affective …

Starting with the work of Cajal more than 100 years ago, neuroscience has sought to
understand how the cells of the brain give rise to cognitive functions. How far has …

Assemblies of neurons, called concepts cells, encode acquired concepts in human Medial
Temporal Lobe. Those concept cells that are shared between two assemblies have been …

Childhood adversity increases the risk of develo** psychiatric symptoms later in life.
However, the neurobiological mechanisms underlying this association are unknown. This …