With approximately 1% of proteins being flavoproteins, flavins are at the heart of a plethora
of redox reactions in all areas of biology. Thanks to a series of fascinating recent …

Highlights•The versatile chemistry of the flavin cofactor underpins a wide range of enzyme
reactions.•New flavin species have recently been discovered, including prenylated flavins …

Epoxide ring opening reactions are common and important in both biological processes and
synthetic applications and can be catalyzed in a non-redox manner by epoxide hydrolases …

The folate biosynthetic pathway offers many druggable targets that have yet to be exploited
in tuberculosis therapy. Herein, we have identified a series of small molecules that interrupt …

Tuberculosis is still an urgent global health problem, mainly due to the spread of multi-drug
resistant M. tuberculosis strains, which lead to the need of new more efficient drugs. A …

Conspectus RNA modifications found in most RNAs, particularly in tRNAs and rRNAs, reveal
an abundance of chemical alterations of nucleotides. Over 150 distinct RNA modifications …

Asgard archaea include the closest known archaeal relatives of eukaryotes. Here, we
investigate the evolution and function of Asgard thymidylate synthases and other folate …

The evolutionarily conserved bacterial proteins MnmE and MnmG (and their homologues in
Eukarya) install a 5-carboxymethylaminomethyl (cmnm5) or a 5-taurinomethyl (τm5) group …

Folate enzyme cofactors and their derivatives have the unique ability to provide a single
carbon unit at different oxidation levels for the de novo synthesis of amino-acids, purines, or …

RNA methylation is the most abundant and evolutionarily conserved chemical modification
of bases or ribose in noncoding and coding RNAs. This rather simple modification has …