Toll-like receptor signal transduction
Toll-like receptors (TLRs) are the archetypal pattern recognition receptors in sensing
exogenous pathogens. Activation of TLRs is a first line of defense of the immune system …
exogenous pathogens. Activation of TLRs is a first line of defense of the immune system …
[HTML][HTML] Central nervous system mechanisms linking the consumption of palatable high-fat diets to the defense of greater adiposity
The central nervous system (CNS) plays key role in the homeostatic regulation of body
weight. Satiation and adiposity signals, providing acute and chronic information about …
weight. Satiation and adiposity signals, providing acute and chronic information about …
Elevated pre-activation basal level of nuclear NF-κB in native macrophages accelerates LPS-induced translocation of cytosolic NF-κB into the cell nucleus
AV Bagaev, AY Garaeva, ES Lebedeva, AV Pichugin… - Scientific reports, 2019 - nature.com
Signaling via Toll-like receptor 4 (TLR4) in macrophages constitutes an essential part of the
innate immune response to bacterial infections. Detailed and quantified descriptions of …
innate immune response to bacterial infections. Detailed and quantified descriptions of …
CXCL10 impairs β cell function and viability in diabetes through TLR4 signaling
FT Schulthess, F Paroni, NS Sauter, L Shu, P Ribaux… - Cell metabolism, 2009 - cell.com
In type 1 and type 2 diabetes (T1/T2DM), β cell destruction by apoptosis results in decreased
β cell mass and progression of the disease. In this study, we found that the interferon γ …
β cell mass and progression of the disease. In this study, we found that the interferon γ …
Systems biology approach for enhancing limonene yield by re-engineering Escherichia coli
Engineered microorganisms have emerged as viable alternatives for limonene production.
However, issues such as low enzyme abundance or activities, and regulatory …
However, issues such as low enzyme abundance or activities, and regulatory …
A systems biology approach to suppress TNF-induced proinflammatory gene expressions
Background Tumor necrosis factor (TNF) is a widely studied cytokine (ligand) that induces
proinflammatory signaling and regulates myriad cellular processes. In major illnesses, such …
proinflammatory signaling and regulates myriad cellular processes. In major illnesses, such …
Systems biology to understand and regulate human retroviral proinflammatory response
The majority of human genome are non-coding genes. Recent research have revealed that
about half of these genome sequences make up of transposable elements (TEs). A branch …
about half of these genome sequences make up of transposable elements (TEs). A branch …
Signaling flux redistribution at toll-like receptor pathway junctions
Various receptors on cell surface recognize specific extracellular molecules and trigger
signal transduction altering gene expression in the nucleus. Gain or loss-of-function …
signal transduction altering gene expression in the nucleus. Gain or loss-of-function …
Is central dogma a global property of cellular information flow?
The central dogma of molecular biology has come under scrutiny in recent years. Here, we
reviewed high-throughput mRNA and protein expression data of Escherichia coli …
reviewed high-throughput mRNA and protein expression data of Escherichia coli …
Local and global responses in complex gene regulation networks
An exacerbated sensitivity to apparently minor stimuli and a general resilience of the entire
system stay together side-by-side in biological systems. This apparent paradox can be …
system stay together side-by-side in biological systems. This apparent paradox can be …