[HTML][HTML] Brain GABA and glutamate levels across pain conditions: a systematic literature review and meta-analysis of 1H-MRS studies using the MRS-Q quality …

AL Peek, T Rebbeck, NAJ Puts, J Watson, MER Aguila… - Neuroimage, 2020 - Elsevier
Background A proposed mechanism of chronic pain is dysregulation between the main
inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system …

[HTML][HTML] The role of MRS-assessed GABA in human behavioral performance

H Li, KF Heise, S Chalavi, NAJ Puts, RAE Edden… - Progress in …, 2022 - Elsevier
Understanding the neurophysiological mechanisms that drive human behavior has been a
long-standing focus of cognitive neuroscience. One well-known neuro-metabolite involved …

Big GABA: Edited MR spectroscopy at 24 research sites

M Mikkelsen, PB Barker, PK Bhattacharyya, MK Brix… - Neuroimage, 2017 - Elsevier
Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can
noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid …

Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites

M Mikkelsen, DL Rimbault, PB Barker… - Neuroimage, 2019 - Elsevier
Accurate and reliable quantification of brain metabolites measured in vivo using 1 H
magnetic resonance spectroscopy (MRS) is a topic of continued interest. Aside from …

Comparison of seven modelling algorithms for γ‐aminobutyric acid–edited proton magnetic resonance spectroscopy

AR Craven, PK Bhattacharyya, WT Clarke… - NMR in …, 2022 - Wiley Online Library
Edited MRS sequences are widely used for studying γ‐aminobutyric acid (GABA) in the
human brain. Several algorithms are available for modelling these data, deriving metabolite …

[HTML][HTML] Transcranial magnetic stimulation and magnetic resonance spectroscopy: Opportunities for a bimodal approach in human neuroscience

K Cuypers, A Marsman - Neuroimage, 2021 - Elsevier
Over the last decade, there has been an increasing number of studies combining
transcranial magnetic stimulation (TMS) and magnetic resonance spectroscopy (MRS). MRS …

Randomised controlled trial of simvastatin treatment for autism in young children with neurofibromatosis type 1 (SANTA)

S Stivaros, S Garg, M Tziraki, Y Cai, O Thomas… - Molecular autism, 2018 - Springer
Abstract Background Neurofibromatosis 1 (NF1) is a monogenic model for syndromic
autism. Statins rescue the social and cognitive phenotype in animal knockout models, but …

A comprehensive guide to MEGA-PRESS for GABA measurement

AL Peek, TJ Rebbeck, AM Leaver, SL Foster… - Analytical …, 2023 - Elsevier
The aim of this guideline is to provide a series of evidence-based recommendations that
allow those new to using MEGA-PRESS to produce high-quality data for the measurement of …

[HTML][HTML] Regional balance between glutamate+ glutamine and GABA+ in the resting human brain

A Steel, M Mikkelsen, RAE Edden, CE Robertson - Neuroimage, 2020 - Elsevier
Abstract Models of healthy brain function and psychiatric conditions assume that excitatory
and inhibitory activity are balanced in the human brain at multiple spatial and temporal …

Age‐related differences in GABA levels are driven by bulk tissue changes

C Maes, L Hermans, L Pauwels, S Chalavi… - Human Brain …, 2018 - Wiley Online Library
Levels of GABA, the main inhibitory neurotransmitter in the brain, can be regionally
quantified using magnetic resonance spectroscopy (MRS). Although GABA is crucial for …