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YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
S Piccolo, T Panciera, P Contessotto, M Cordenonsi - Nature cancer, 2023 - nature.com
Our understanding of the function of the transcriptional regulators YAP and TAZ (YAP/TAZ)
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
in cancer is advancing. In this Review, we provide an update on recent progress in YAP/TAZ …
Cancer stem cells: Advances in knowledge and implications for cancer therapy
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …
The Hippo signalling pathway and its implications in human health and diseases
As an evolutionarily conserved signalling network, the Hippo pathway plays a crucial role in
the regulation of numerous biological processes. Thus, substantial efforts have been made …
the regulation of numerous biological processes. Thus, substantial efforts have been made …
[HTML][HTML] Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …
Cancer stem cell–immune cell crosstalk in tumour progression
Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …
independent yet synergistic drivers of tumour progression and underlie therapeutic …
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironment
Liver metastasis is a major cause of death in patients with colorectal cancer (CRC). Fatty
liver promotes liver metastasis, but the underlying mechanism remains unclear. We …
liver promotes liver metastasis, but the underlying mechanism remains unclear. We …
Hallmarks of cancer stemness
Cancer stemness is recognized as a key component of tumor development. Previously
coined" cancer stem cells"(CSCs) and believed to be a rare population with rigid …
coined" cancer stem cells"(CSCs) and believed to be a rare population with rigid …
[HTML][HTML] Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer
Stromal desmoplastic reaction in pancreatic ductal adenocarcinoma (PDAC) involves
significant accumulation of type I collagen (Col1). However, the precise molecular and …
significant accumulation of type I collagen (Col1). However, the precise molecular and …
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
CD8+ T cell-mediated cancer clearance is often suppressed by the interaction between
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
inhibitory molecules like PD-1 and PD-L1, an interaction acts like brakes to prevent T cell …
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …
signalling pathways. One such pathway that has garnered much attention in the field of …