Pyridine (py) is an important heterocyclic compound and is an integral part of various natural
products. There are various medicines containing py ring system being available in the …

Serine/threonine-protein kinase B-Raf (BRAF; RAF= rapidly accelerated fibrosarcoma) plays
an important role in the mitogen-activated protein kinase (MAPK) signaling cascade …

Malignant melanoma (MM) is the most lethal skin cancer. Despite a 4% reduction in mortality
over the past few years, an increasing number of new diagnosed cases appear each year …

A new series of N-(2-((4-(1, 3-diphenyl-1H-pyrazol-4-yl) pyridine sulfonamide derivatives
11a-o were designed and synthesized based on our previous works. The new series was …

Pyridine-based ring structures are widely employed in drug design due to their significant
impact on pharmacological activity, resulting in the development of various broad-spectrum …

Abstract BRAF V600E mutation has been detected in various malignant tumours.
Develo** of potent BRAF V600E inhibitors is considered a leading step in the way to cure …

BRAF is the most common serine-threonine protein kinase and regulates signal transduction
from RAS to MEK inside the cell. The BRAF is a highly active isoform of RAF kinase. BRAF …

The mitogen activated protein kinase (MAPK) belongs to group of kinase that links the
extracellular stimuli to intracellular response. The MAPK signalling pathway (RAS-RAF-MEK …

Cancer is one of the major public catastrophes worldwide and as per WHO, cancer is the
leading cause of death universally after CVS disorders accounting for 9.6 million deaths in …

In the present work, a new series of ethyl pyrazole-containing compounds with side
sulphonamide moiety was designed and synthesized. The new derivatives were divided into …