The prefrontal cortex (PFC) has emerged as one of the regions most consistently impaired in
major depressive disorder (MDD). Although functional and structural PFC abnormalities …

Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

Placebo effects are notable demonstrations of mind–body interactions,. During pain
perception, in the absence of any treatment, an expectation of pain relief can reduce the …

Objective: Repetitive transcranial magnetic stimulation (rTMS) protocols increasingly use
subgenual anterior cingulate cortex (sgACC) functional connectivity to individualize …

Acute pain is a physiological response that causes an unpleasant sensory and emotional
experience in the presence of actual or potential tissue injury. Anatomically and …

Characterizing cerebral contributions to individual variability in pain processing is crucial for
personalized pain medicine, but has yet to be done. In the present study, we address this …

Pain is considered a multidimensional experience that embodies not merely sensation, but
also emotion and perception. As is appropriate for this complexity, pain is represented and …

(1) Background: In recent years, placebo and nocebo effects have been extensively
documented in different medical conditions, including pain. The scientific literature has …

Drug treatments for pain often do not outperform placebo, and a better understanding of
placebo mechanisms is needed to improve treatment development and clinical practice. In a …

Pain is a fundamental experience that promotes survival. In humans, pain stands at the
intersection of multiple health crises: chronic pain, the opioid epidemic, and health …