Serine hydrolases perform crucial roles in many biological processes, and several of these
enzymes are targets of approved drugs for indications such as type 2 diabetes, Alzheimer's …

This review focuses on recent trends in multiple sequence alignment tools. It describes the
latest algorithmic improvements including the extension of consistency-based methods to …

Long-term climate change and periodic environmental extremes threaten food and fuel
security and global crop productivity,–. Although molecular and adaptive breeding strategies …

Ammonia-oxidising archaea (AOA) are ubiquitous and abundant in nature and play a major
role in nitrogen cycling. AOA have been studied intensively based on the amoA gene …

Identifying master regulators of biological processes and map** their downstream gene
networks are key challenges in systems biology. We developed a computational method …

INTRODUCTION Crocodilians and birds are the two extant clades of archosaurs, a group
that includes the extinct dinosaurs and pterosaurs. Fossils suggest that living crocodilians …

The origin of eukaryotes stands as a major conundrum in biology. Current evidence
indicates that the last eukaryotic common ancestor already possessed many eukaryotic …

Phylogenetic inference is generally performed on the basis of multiple sequence alignments
(MSA). Because errors in an alignment can lead to errors in tree estimation, there is a strong …

Multiple comparison or alignmentof protein sequences has become a fundamental tool in
many different domains in modern molecular biology, from evolutionary studies to prediction …

The nutrient-rich tubers of the greater yam, Dioscorea alata L., provide food and income
security for millions of people around the world. Despite its global importance, however …