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Ubiquitin ligases: guardians of mammalian development
DA Cruz Walma, Z Chen, AN Bullock… - … Reviews Molecular Cell …, 2022 - nature.com
Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …
located in temporal order, and their function regulated, to orchestrate important steps in cell …
Context-specific Polycomb mechanisms in development
Polycomb group (PcG) proteins are crucial chromatin regulators that maintain repression of
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
lineage-inappropriate genes and are therefore required for stable cell fate. Recent advances …
Male gametes are generated through a specialised differentiation pathway involving a
series of developmental transitions that are poorly characterised at the molecular level …
series of developmental transitions that are poorly characterised at the molecular level …
Novel techniques of sperm selection for improving IVF and ICSI outcomes
I Oseguera-López, S Ruiz-Díaz… - Frontiers in cell and …, 2019 - frontiersin.org
Almost 50% of the infertility cases are due to male factors. Assisted reproductive
technologies (ARTs) allow to overcome the incapacity of these patients' spermatozoa to …
technologies (ARTs) allow to overcome the incapacity of these patients' spermatozoa to …
Meiotic silencing in mammals
JMA Turner - Annual review of genetics, 2015 - annualreviews.org
Meiosis is essential for reproduction in sexually reproducing organisms. A key stage in
meiosis is the synapsis of maternal and paternal homologous chromosomes, accompanied …
meiosis is the synapsis of maternal and paternal homologous chromosomes, accompanied …
Meiotic recombination: insights into its mechanisms and its role in human reproduction with a special focus on non-obstructive azoospermia
C **e, W Wang, C Tu, L Meng, G Lu… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Meiosis is an essential stage in the life cycle of sexually reproducing
species, underlying formation of haploid gametes and serving as the basis of genetic …
species, underlying formation of haploid gametes and serving as the basis of genetic …
[HTML][HTML] High-throughput single-cell sequencing with linear amplification
Conventional methods for single-cell genome sequencing are limited with respect to
uniformity and throughput. Here, we describe sci-L3, a single-cell sequencing method that …
uniformity and throughput. Here, we describe sci-L3, a single-cell sequencing method that …
Attenuated chromatin compartmentalization in meiosis and its maturation in sperm development
Germ cells manifest a unique gene expression program and regain totipotency in the zygote.
Here, we perform Hi-C analysis to examine 3D chromatin organization in male germ cells …
Here, we perform Hi-C analysis to examine 3D chromatin organization in male germ cells …
Molecular regulation of spermatogonial stem cell renewal and differentiation
JA Mäkelä, RM Hobbs - Reproduction, 2019 - rep.bioscientifica.com
The intricate molecular and cellular interactions between spermatogonial stem cells (SSCs)
and their cognate niche form the basis for life-long sperm production. To maintain long-term …
and their cognate niche form the basis for life-long sperm production. To maintain long-term …
[PDF][PDF] Dynamic reorganization of open chromatin underlies diverse transcriptomes during spermatogenesis
S Maezawa, M Yukawa, KG Alavattam… - Nucleic acids …, 2018 - academic.oup.com
During spermatogenesis, germ cells undergo massive cellular reconstruction and dynamic
chromatin remodeling to facilitate highly diverse transcriptomes, which are required for the …
chromatin remodeling to facilitate highly diverse transcriptomes, which are required for the …