Polycystic ovary syndrome (PCOS) is among the most common disorders in women of
reproductive age, affecting up to 15% worldwide, depending on the diagnostic criteria …

The year 2021 marks the centennial of Banting and Best's landmark description of the
discovery of insulin. This discovery and insulin's rapid clinical deployment effectively …

Regular exercise is a formidable regulator of insulin sensitivity and overall systemic
metabolism through both acute events driven by each exercise bout and through chronic …

The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …

Glucose levels in blood must be constantly maintained within a tight physiological range to
sustain anabolism. Insulin regulates glucose homeostasis via its effects on glucose …

Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …

Shift workers, who are exposed to irregular sleep schedules resulting in sleep deprivation
and misalignment of circadian rhythms, have an increased risk of diabetes relative to day …

Gestational diabetes (GDM) is defined as a glucose intolerance resulting in hyperglycaemia
of variable severity with onset during pregnancy. This review aims to revisit the …

Background For patients with obesity and type 2 diabetes, weight loss improves insulin
sensitivity and β-cell function, and can induce remission of diabetes. The comparative …

Metabolomic profiling of obese versus lean humans reveals a branched-chain amino acid
(BCAA)-related metabolite signature that is suggestive of increased catabolism of BCAA and …