[HTML][HTML] The pilocarpine model of temporal lobe epilepsy
Understanding the pathophysiogenesis of temporal lobe epilepsy (TLE) largely rests on the
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …
use of models of status epilepticus (SE), as in the case of the pilocarpine model. The main …
Neural coding with bursts—current state and future perspectives
Neuronal action potentials or spikes provide a long-range, noise-resistant means of
communication between neurons. As point processes single spikes contain little information …
communication between neurons. As point processes single spikes contain little information …
Interictal spikes and epileptic seizures: their relationship and underlying rhythmicity
We report on a quantitative analysis of electrocorticography data from a study that acquired
continuous ambulatory recordings in humans over extended periods of time. The objectives …
continuous ambulatory recordings in humans over extended periods of time. The objectives …
How can we identify ictal and interictal abnormal activity?
RS Fisher, HE Scharfman, M DeCurtis - … in clinical epileptology: A view from …, 2014 - Springer
Abstract The International League Against Epilepsy (ILAE) defined a seizure as “a transient
occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal …
occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal …
Astroglial Excitability and Gliotransmission: An Appraisal of Ca2+ as a Signalling Route
Astroglial cells, due to their passive electrical properties, were long considered subservient
to neurons and to merely provide the framework and metabolic support of the brain …
to neurons and to merely provide the framework and metabolic support of the brain …
Glutamatergic pre-ictal discharges emerge at the transition to seizure in human epilepsy
The mechanisms involved in the transition to an epileptic seizure remain unclear. To
examine them, we used tissue slices from human subjects with mesial temporal lobe …
examine them, we used tissue slices from human subjects with mesial temporal lobe …
GABAergic synchronization in the limbic system and its role in the generation of epileptiform activity
M Avoli, M de Curtis - Progress in neurobiology, 2011 - Elsevier
GABA is the main inhibitory neurotransmitter in the adult forebrain, where it activates
ionotropic type A and metabotropic type B receptors. Early studies have shown that GABAA …
ionotropic type A and metabotropic type B receptors. Early studies have shown that GABAA …
Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic?
Temporal lobe epilepsy (TLE) is frequently associated with hippocampal sclerosis, possibly
caused by a primary brain injury that occurred a long time before the appearance of …
caused by a primary brain injury that occurred a long time before the appearance of …
Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
JA Gorter, EA van Vliet, E Aronica, T Breit… - Journal of …, 2006 - Soc Neuroscience
To get insight into the mechanisms that may lead to progression of temporal lobe epilepsy,
we investigated gene expression during epileptogenesis in the rat. RNA was obtained from …
we investigated gene expression during epileptogenesis in the rat. RNA was obtained from …
Excitatory effects of parvalbumin-expressing interneurons maintain hippocampal epileptiform activity via synchronous afterdischarges
Epileptic seizures are characterized by periods of hypersynchronous, hyperexcitability within
brain networks. Most seizures involve two stages: an initial tonic phase, followed by a longer …
brain networks. Most seizures involve two stages: an initial tonic phase, followed by a longer …