[HTML][HTML] Molecular mechanism pathways of natural compounds for the treatment of non-alcoholic fatty liver disease

X Fang, J Song, K Zhou, X Zi, B Sun, H Bao, L Li - Molecules, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the
world, and its incidence continues to increase each year. Yet, there is still no definitive drug …

Protective effects of microbiome-derived inosine on lipopolysaccharide-induced acute liver damage and inflammation in mice via mediating the TLR4/NF-κB pathway

W Guo, Q **ang, B Mao, X Tang, S Cui… - Journal of Agricultural …, 2021 - ACS Publications
This research assessed the anti-inflammatory and hepatoprotective properties of inosine
and the associated mechanism. Inosine pretreatment significantly reduced the secretion of …

Diosgenin and its analogs: potential protective agents against atherosclerosis

D Wang, X Wang - Drug Design, Development and Therapy, 2022 - Taylor & Francis
Atherosclerosis is a chronic inflammatory disease of the artery wall associated with lipid
metabolism imbalance and maladaptive immune response, which mediates most …

[HTML][HTML] Diosgenin attenuates non-alcoholic fatty liver disease in type 2 diabetes through regulating SIRT6-related fatty acid uptake

K Nie, Y Gao, S Chen, Z Wang, H Wang, Y Tang, H Su… - Phytomedicine, 2023 - Elsevier
Background More than 70% of patients with type 2 diabetes (T2DM) concomitantly suffer
from Non-alcoholic fatty liver disease (NAFLD), and the coexistence and interaction of them …

[HTML][HTML] Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation

M Yan, S Man, Y Liang, L Ma, L Guo, L Huang… - Pharmacological …, 2023 - Elsevier
Nonalcoholic steatohepatitis (NASH), as the aggressive form of nonalcoholic fatty liver
disease (NAFLD), rapidly becomes the leading cause of end-stage liver disease or liver …

[HTML][HTML] Ethanol extract of licorice alleviates HFD-induced liver fat accumulation in association with modulation of gut microbiota and intestinal metabolites in obesity …

F Liu, X Tang, B Mao, Q Zhang, J Zhao, S Cui, W Chen - Nutrients, 2022 - mdpi.com
As a traditional Chinese medicine, licorice is often used in functional foods for its health
benefits. However, the role of gut microbiota in the efficacy of licorice has not yet been fully …

TRIM21 ameliorates hepatic glucose and lipid metabolic disorders in type 2 diabetes mellitus by ubiquitination of PEPCK1 and FASN

K Zhang, C Yang, X Zhou, J Liang, J Guo, M Li… - Cellular and Molecular …, 2023 - Springer
Hepatic glucose and lipid metabolism disorders promote the development and progression
of type 2 diabetes mellitus (T2DM), yet the underlying mechanisms are not fully understood …

Diosgenin ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and related lipid/amino acid metabolism in high fat diet-fed rats

Y Zhou, R Li, Y Zheng, M Song, S Zhang… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disease closely associated with
dietary habits. Diosgenin is abundant in yam, a common food and traditional Chinese …

[HTML][HTML] Diosgenin ameliorated type II diabetes-associated nonalcoholic fatty liver disease through inhibiting de novo lipogenesis and improving fatty acid oxidation …

Y Zhong, Z Li, R **, Y Yao, S He, M Lei, X Wang, C Shi… - Nutrients, 2022 - mdpi.com
Diosgenin (DIO) is a dietary and phytochemical steroidal saponin representing multiple
activities. The present study investigated the protective effect of DIO on type II diabetes …

Diosgenin: An ingress towards solving puzzle for diabetes treatment

P Arya, P Kumar - Journal of Food Biochemistry, 2022 - Wiley Online Library
The consumption and composition of food in daily life predict our health in long run. The
relation of diabetes to sweets is quite popular. Diabetes hampers the glucose and insulin …