Multiple factors combined are currently recognized as contributors to cognitive decline. The
main independent risk factor for cognitive impairment and dementia is advanced age …

Mitochondrial dysfunctions are central players in Alzheimer's disease (AD). In addition,
impairments in mitophagy, the process of selective mitochondrial degradation by autophagy …

Sirtuins are the class III of histone deacetylases whose deacetylate of histones is dependent
on nicotinamide adenine dinucleotide (NAD+). Among seven sirtuins, SIRT1 plays a critical …

While the elderly segment of the population continues growing in importance,
neurodegenerative diseases increase exponentially. Lifestyle factors such as nutrition …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly.
It is characterized by a progressive and irreversible loss of cognitive abilities and formation …

Alzheimer disease (AD) is a progressive and deleterious neurodegenerative disorder that
affects mostly the elderly population. At the moment, no effective treatments are available in …

Resveratrol is a bioactive compound in many foods. Since its anticancer activity was
reported in 1997, its health benefits have been intensively investigated. Resveratrol has …

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

Alzheimer's disease (AD) is a brain disorder associated with a gradual weakening in
neurocognitive functions, neuroinflammation, and impaired signaling pathways. Resveratrol …