Osteoporosis pathogenesis and treatment: existing and emerging avenues

B Liang, G Burley, S Lin, YC Shi - Cellular & Molecular Biology Letters, 2022‏ - Springer
Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

Ovarian damage from chemotherapy and current approaches to its protection

N Spears, F Lopes, A Stefansdottir… - Human reproduction …, 2019‏ - academic.oup.com
Background Anti-cancer therapy is often a cause of premature ovarian insufficiency and
infertility since the ovarian follicle reserve is extremely sensitive to the effects of …

Genetic insights into biological mechanisms governing human ovarian ageing

KS Ruth, FR Day, J Hussain, A Martínez-Marchal… - Nature, 2021‏ - nature.com
Reproductive longevity is essential for fertility and influences healthy ageing in women,, but
insights into its underlying biological mechanisms and treatments to preserve it are limited …

Parkinson's disease in women and men: what's the difference?

S Cerri, L Mus, F Blandini - Journal of Parkinson's disease, 2019‏ - content.iospress.com
Increasing evidence points to biological sex as an important factor in the development and
phenotypical expression of Parkinson's disease (PD). Risk of develo** PD is twice as high …

Menopausal hormone therapy and women's health: An umbrella review

GQ Zhang, JL Chen, Y Luo, MB Mathur… - PLoS …, 2021‏ - journals.plos.org
Background There remains uncertainty about the impact of menopausal hormone therapy
(MHT) on women's health. A systematic, comprehensive assessment of the effects on …

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

L Mosconi, V Berti, J Dyke, E Schelbaum, S Jett… - Scientific reports, 2021‏ - nature.com
All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …

Research trends in flavonoids and health

F Perez-Vizcaino, CG Fraga - Archives of biochemistry and biophysics, 2018‏ - Elsevier
Herein we describe, based on some bibliometric data, how the field of research on
flavonoids has evolved over the last 25 years. The number of papers on flavonoids has risen …

Estrogen receptors and the aging brain

S Maioli, K Leander, P Nilsson… - Essays in Biochemistry, 2021‏ - portlandpress.com
The female sex hormone estrogen has been ascribed potent neuroprotective properties. It
signals by binding and activating estrogen receptors that, depending on receptor subtype …

Beyond experiments

E Diener, R Northcott, MJ Zyphur… - Perspectives on …, 2022‏ - journals.sagepub.com
It is often claimed that only experiments can support strong causal inferences and therefore
they should be privileged in the behavioral sciences. We disagree. Overvaluing experiments …

The controversial history of hormone replacement therapy

A Cagnacci, M Venier - Medicina, 2019‏ - mdpi.com
The history of hormone replacement therapy (HRT) started in the 1960s, with very high
popularity in the 1990s. The first clinical trials on HRT and chronic postmenopausal …