Nucleic acid molecules possess many superior properties, including high designability and
structural predictability, making them attractive biosensing and bioimaging tools. The …

The chemical composition of cells at the molecular level determines their growth,
differentiation, structure, and function. Probing this composition is powerful because it …

FTO, an mRNA N 6-methyladenosine (m 6 A) demethylase, was reported to promote
leukemogenesis. Using structure-based rational design, we have developed two promising …

Abstract Fluorescent RNAs (FRs), aptamers that bind and activate fluorescent dyes, have
been used to image abundant cellular RNA species. However, limitations such as low …

N 6-methyladenosine (m6A) has emerged as the most abundant mRNA modification that
regulates gene expression in many physiological processes. m6A modification in RNA …

The epigenetic modification of nucleic acids represents a versatile approach for achieving
high-efficient control over gene expression and transcription and could dramatically expand …

Fat mass and obesity-associated proteins (FTO) play an essential role in the reversible
regulation of N6-methyladenosine (m6A) epigenetic modification, and the overexpression of …

Aberrant regulation of N 6-methyladenosine (m6A) RNA modification has been implicated in
the progression of multiple diseases, including cancer. Previously, we identified a small …

Single‐cell epigenetics is envisioned to decipher manifold epigenetic phenomena and to
contribute to our accurate knowledge about basic epigenetic mechanisms. Engineered …

Seeing is not only believing; it also includes understanding. Cellular imaging with GFP in
live cells has been transformative in many research fields. Modulation of cellular regulation …