Neural circuitry of wakefulness and sleep

TE Scammell, E Arrigoni, JO Lipton - Neuron, 2017 - cell.com
Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review
current perspectives on the neural systems that regulate sleep/wake states in mammals and …

Sleep and circadian rhythmicity as entangled processes serving homeostasis

P Franken, DJ Dijk - Nature Reviews Neuroscience, 2024 - nature.com
Sleep is considered essential for the brain and body. A predominant concept is that sleep is
regulated by circadian rhythmicity and sleep homeostasis, processes that were posited to be …

Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback

PM Fuller, JJ Gooley, CB Saper - Journal of biological …, 2006 - journals.sagepub.com
This mini-review article presents the remarkable progress that has been made in the past
decade in our understanding of the neural circuitry underlying the regulation of sleep-wake …

Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm

RL Sack, D Auckley, RR Auger, MA Carskadon… - Sleep, 2007 - academic.oup.com
Objective: This the second of two articles reviewing the scientific literature on the evaluation
and treatment of circadian rhythm sleep disorders (CRSDs), employing the methodology of …

[BOOK][B] Circadian physiology

R Refinetti - 2016 - books.google.com
Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

SCN outputs and the hypothalamic balance of life

A Kalsbeek, IF Palm, SE La Fleur… - Journal of biological …, 2006 - journals.sagepub.com
The circadian clock in the suprachiasmatic nucleus (SCN) is composed of thousands of
oscillator neurons, each dependent on the cell-autonomous action of a defined set of …

Functional neuroanatomy of the central noradrenergic system

E Szabadi - Journal of psychopharmacology, 2013 - journals.sagepub.com
The central noradrenergic neurone, like the peripheral sympathetic neurone, is
characterized by a diffusely arborizing terminal axonal network. The central neurones …

Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations

WD Todd, A Venner, C Anaclet, RY Broadhurst… - Nature …, 2020 - nature.com
The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined
cell groups that contribute to the genesis of circadian rhythms. Using cell-specific and …

Sex differences in circadian timing systems: implications for disease

M Bailey, R Silver - Frontiers in neuroendocrinology, 2014 - Elsevier
Virtually every eukaryotic cell has an endogenous circadian clock and a biological sex.
These cell-based clocks have been conceptualized as oscillators whose phase can be reset …

PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit

KM Parisky, J Agosto, SR Pulver, Y Shang, E Kuklin… - Neuron, 2008 - cell.com
Daily sleep cycles in humans are driven by a complex circuit within which GABAergic sleep-
promoting neurons oppose arousal. Drosophila sleep has recently been shown to be …