The pe/ppe genes represent one of the most intriguing aspects of the M ycobacterium
tuberculosis genome. These genes are especially abundant in pathogenic mycobacteria …

Molecular ty** has revolutionized epidemiological studies of infectious diseases,
including those of a mycobacterial etiology. With the advent of fingerprinting techniques …

Among various genoty** methods to study Mycobacterium tuberculosis complex (MTC)
genotypic polymorphism, spoligoty** and mycobacterial interspersed repetitive units …

Identification of new drug targets is vital for the advancement of drug discovery against
Mycobacterium tuberculosis, especially given the increase of resistance worldwide to first …

Insertion sequences (ISs) are abundant mobile genetic elements on bacterial genomes,
responsible for mobilization of many genes, including antibiotic resistance genes (ARGs). As …

The publication of the complete genome sequence for Mycobacterium tuberculosis H37Rv
in 1998 has had a great impact on the research community. Nonetheless, it is suspected that …

Transposable elements (TEs) were first discovered more than 50 years ago, but were totally
ignored for a long time. Over the last few decades they have gradually attracted increasing …

Background Insertion sequences (IS) are small transposable elements, commonly found in
bacterial genomes. Identifying the location of IS in bacterial genomes can be useful for a …

DNA methylation regulates gene expression in many organisms. In eukaryotes, DNA
methylation is associated with gene repression, while it exerts both activating and repressive …

Many of the most virulent bacterial pathogens show low genetic diversity and sexual
isolation. Accordingly, Mycobacterium tuberculosis, the deadliest human pathogen, is …