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Heterologous expression of bacterial natural product biosynthetic pathways
Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …
pathways is of increasing interest in microbial biotechnology, drug discovery and …
[HTML][HTML] Marine biosurfactants: biosynthesis, structural diversity and biotechnological applications
Biosurfactants are amphiphilic secondary metabolites produced by microorganisms. Marine
bacteria have recently emerged as a rich source for these natural products which exhibit …
bacteria have recently emerged as a rich source for these natural products which exhibit …
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A
Recent developments in next-generation sequencing technologies have brought recognition
of microbial genomes as a rich resource for novel natural product discovery. However …
of microbial genomes as a rich resource for novel natural product discovery. However …
Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery
SB Zotchev - Microbial Biotechnology, 2024 - Wiley Online Library
Among the plant‐associated microorganisms, the so‐called endophytes continue to attract
much attention because of their ability not only to protect host plants from biotic and abiotic …
much attention because of their ability not only to protect host plants from biotic and abiotic …
Microbial chassis engineering drives heterologous production of complex secondary metabolites
The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …
Genetic platforms for heterologous expression of microbial natural products
Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …
ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes
H Wang, Z Li, R Jia, J Yin, A Li, L **a, Y Yin… - Nucleic acids …, 2018 - academic.oup.com
The exponentially increasing volumes of DNA sequence data highlight the need for new
DNA cloning methods to explore the new information. Here, we describe 'ExoCET'(Exo …
DNA cloning methods to explore the new information. Here, we describe 'ExoCET'(Exo …
Reinvigorating natural product combinatorial biosynthesis with synthetic biology
Natural products continue to play a pivotal role in drug-discovery efforts and in the
understanding of human health. The ability to extend nature's chemistry through …
understanding of human health. The ability to extend nature's chemistry through …
Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes
Actinomycetes are excellent sources for novel bioactive compounds, which serve as
potential drug candidates for antibiotics development. While industrial efforts to find and …
potential drug candidates for antibiotics development. While industrial efforts to find and …
RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression
H Wang, Z Li, R Jia, Y Hou, J Yin, X Bian, A Li… - Nature protocols, 2016 - nature.com
Abstract Full-length RecE and RecT from Rac prophage mediate highly efficient linear–
linear homologous recombination that can be used to clone large DNA regions directly from …
linear homologous recombination that can be used to clone large DNA regions directly from …