Heterologous expression of bacterial natural product biosynthetic pathways

L Huo, JJ Hug, C Fu, X Bian, Y Zhang… - Natural product reports, 2019 - pubs.rsc.org
Covering: 2013 to June 2018 Heterologous expression of natural product biosynthetic
pathways is of increasing interest in microbial biotechnology, drug discovery and …

[HTML][HTML] Marine biosurfactants: biosynthesis, structural diversity and biotechnological applications

S Kubicki, A Bollinger, N Katzke, KE Jaeger… - Marine drugs, 2019 - mdpi.com
Biosurfactants are amphiphilic secondary metabolites produced by microorganisms. Marine
bacteria have recently emerged as a rich source for these natural products which exhibit …

Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A

K Yamanaka, KA Reynolds, RD Kersten… - Proceedings of the …, 2014 - pnas.org
Recent developments in next-generation sequencing technologies have brought recognition
of microbial genomes as a rich resource for novel natural product discovery. However …

Unlocking the potential of bacterial endophytes from medicinal plants for drug discovery

SB Zotchev - Microbial Biotechnology, 2024 - Wiley Online Library
Among the plant‐associated microorganisms, the so‐called endophytes continue to attract
much attention because of their ability not only to protect host plants from biotic and abiotic …

Microbial chassis engineering drives heterologous production of complex secondary metabolites

J Liu, X Wang, G Dai, Y Zhang, X Bian - Biotechnology Advances, 2022 - Elsevier
The cryptic secondary metabolite biosynthetic gene clusters (BGCs) far outnumber currently
known secondary metabolites. Heterologous production of secondary metabolite BGCs in …

Genetic platforms for heterologous expression of microbial natural products

JJ Zhang, X Tang, BS Moore - Natural product reports, 2019 - pubs.rsc.org
Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes

H Wang, Z Li, R Jia, J Yin, A Li, L **a, Y Yin… - Nucleic acids …, 2018 - academic.oup.com
The exponentially increasing volumes of DNA sequence data highlight the need for new
DNA cloning methods to explore the new information. Here, we describe 'ExoCET'(Exo …

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

E Kim, BS Moore, YJ Yoon - Nature chemical biology, 2015 - nature.com
Natural products continue to play a pivotal role in drug-discovery efforts and in the
understanding of human health. The ability to extend nature's chemistry through …

Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes

T Weber, P Charusanti, EM Musiol-Kroll, X Jiang… - Trends in …, 2015 - cell.com
Actinomycetes are excellent sources for novel bioactive compounds, which serve as
potential drug candidates for antibiotics development. While industrial efforts to find and …

RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression

H Wang, Z Li, R Jia, Y Hou, J Yin, X Bian, A Li… - Nature protocols, 2016 - nature.com
Abstract Full-length RecE and RecT from Rac prophage mediate highly efficient linear–
linear homologous recombination that can be used to clone large DNA regions directly from …