Abstract Calcium ions (Ca2+) are some of the most versatile signalling molecules, and they
have many physiological functions, prominently including muscle contraction, neuronal …

Mitochondria calcium is a double-edged sword. While low levels of calcium are essential to
maintain optimal rates of ATP production, extreme levels of calcium overcoming the …

Endogenous essential metal ions play an important role in many life processes, especially in
tumor development and immune response. The approval of various metallodrugs for tumor …

The endoplasmic reticulum (ER) and mitochondria cannot be considered as static structures,
as they intimately communicate, forming very dynamic platforms termed mitochondria …

Drug-free macromolecular therapeutics are promising alternatives to traditional drugs.
Nanomedicines with multiple organelles targeting can potentially increase the efficacy …

Genomic instability is a primary cause and fundamental feature of human cancer. However,
all cancer cell genotypes generally translate into several common pathophysiological …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

Abstract BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that
modulates environmental carcinogenesis,,. All carriers of inherited heterozygous germline …

Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …

Oxidative stress caused by an imbalanced metabolism and an excess of reactive oxygen
species (ROS) lead to a range of health disorders in humans. Our endogenous antioxidant …