Abstract Interleukin-2 and interleukin-15 have pivotal roles in the control of the life and death
of lymphocytes. Although their heterotrimeric receptors have two receptor subunits in …

PURPOSE: To provide recommendations for the use of immunosuppressive drugs in the
treatment of patients with ocular inflammatory disorders. PARTICIPANTS: A 12-person panel …

Advancing our understanding of mechanisms of immune regulation in allergy, asthma,
autoimmune diseases, tumor development, organ transplantation, and chronic infections …

Autoimmune and inflammatory uveitis are a group of potentially blinding intraocular
inflammatory diseases that arise without a known infectious trigger and are often associated …

T-helper type 17 cells (TH17) are implicated in rodent models of immune-mediated
diseases. Here we report their involvement in human uveitis and scleritis, and validate our …

IL2 and IL15, members of the 4α-helix bundle family of cytokines, play pivotal roles in the
control of the life and death of lymphocytes. Although their heterotrimeric receptors have two …

The term uveitis encompasses a very diverse group of inflammatory ocular diseases that
cause a significant burden of legal and economic blindness. Indeed, the socioeconomic …

Administration of daclizumab, a humanized mAb directed against the IL-2Rα chain, strongly
reduces brain inflammation in multiple sclerosis patients. Here we show that daclizumab …

Cytokines play an important role in host defense against microorganisms. They orchestrate
innate immunity by inducing protective local inflammation and systemic acute phase …

Although the concept of a separate lineage of T cells specifically equipped to suppress
immune responses was initially proposed more than 30 years ago, progress in this area of …