Biophysical cues, such as mechanical properties, play a critical role in tissue growth and
homeostasis. During organ development and tissue injury repair, compressive and tensional …

The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator
of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous …

Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-
existing blood vessels. The process of development of the proper vascular network is a …

The transcriptional regulators YAP and TAZ are the focus of intense interest given their
remarkable biological properties in development, tissue homeostasis and cancer. YAP and …

Basal cell carcinoma (BCC) of the skin is the most common malignant neoplasm in humans.
BCC is primarily driven by the Sonic Hedgehog (Hh) pathway. However, its phenotypic …

The plasma membrane allows the cell to sense and adapt to changes in the extracellular
environment by relaying external inputs via intracellular signaling networks. One central …

The function of biomolecular condensates is often restricted by condensate dissolution.
Whether condensates can be suppressed without condensate dissolution is unclear. Here …

The Hippo signalling pathway is an emerging growth control and tumour suppressor
pathway that regulates cell proliferation and stem cell functions. Defects in Hippo signalling …

Control of cell number is crucial in animal development and tissue homeostasis, and its
dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in …

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue
homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss …