[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
TRPA1 as a therapeutic target for nociceptive pain
D Souza Monteiro de Araujo, R Nassini… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …
Transient receptor potential channels as drug targets: from the science of basic research to the art of medicine
The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …
Reward and motivation in pain and pain relief
Pain is fundamentally unpleasant, a feature that protects the organism by promoting
motivation and learning. Relief of aversive states, including pain, is rewarding. The …
motivation and learning. Relief of aversive states, including pain, is rewarding. The …
Transient receptor potential (TRP) channels: a clinical perspective
Y Kaneko, A Szallasi - British journal of pharmacology, 2014 - Wiley Online Library
Transient receptor potential (TRP) channels are important mediators of sensory signals with
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
marked effects on cellular functions and signalling pathways. Indeed, mutations in genes …
TRPA1: A gatekeeper for inflammation
DM Bautista, M Pellegrino… - Annual review of …, 2013 - annualreviews.org
Tissue damage evokes an inflammatory response that promotes the removal of harmful
stimuli, tissue repair, and protective behaviors to prevent further damage and encourage …
stimuli, tissue repair, and protective behaviors to prevent further damage and encourage …
Behavioral and cognitive animal models in headache research
Animal models have provided a growing body of information about the pathophysiology of
headaches and novel therapeutic targets. In recent years, experiments in awake animals …
headaches and novel therapeutic targets. In recent years, experiments in awake animals …
Pros and cons of clinically relevant methods to assess pain in rodents
The primary objective of preclinical pain research is to improve the treatment of pain.
Decades of research using pain-evoked tests has revealed much about mechanisms but …
Decades of research using pain-evoked tests has revealed much about mechanisms but …
Pain relief produces negative reinforcement through activation of mesolimbic reward–valuation circuitry
Relief of pain is rewarding. Using a model of experimental postsurgical pain we show that
blockade of afferent input from the injury with local anesthetic elicits conditioned place …
blockade of afferent input from the injury with local anesthetic elicits conditioned place …
TACAN is an ion channel involved in sensing mechanical pain
Mechanotransduction, the conversion of mechanical stimuli into electrical signals, is a
fundamental process underlying essential physiological functions such as touch and pain …
fundamental process underlying essential physiological functions such as touch and pain …