Cancer-associated cachexia is a disorder characterized by loss of body weight with specific
losses of skeletal muscle and adipose tissue. Cachexia is driven by a variable combination …

Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as
cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by …

Cachexia is a severe complication of cancer that adversely affects the course of the disease,
with currently no effective treatments. It is characterized by a progressive atrophy of skeletal …

Signal transducer and activator of transcription (STAT) 3 plays a central role in the host
response to injury. It is activated rapidly within cells by many cytokines, most notably those in …

Cancer cachexia (CC) is a complex syndrome of bodily wasting and progressive functional
decline. Unlike starvation, cachexia cannot be reversed by increased energy intake alone …

Obesity is characterized by chronic and low-grade systemic inflammation, an increase of
adipose tissue, hypertrophy, and hyperplasia of adipocytes. Adipose tissues can be …

It is well established that breast cancer development and progression depend not only on
tumor-cell intrinsic factors but also on its microenvironment and on the host characteristics …

The incidence of metabolism-related diseases like obesity and type 2 diabetes mellitus has
reached pandemic levels worldwide and increased gradually. Most of them are listed on the …

Obesity is a leading risk factor for cancer. However, understanding the crosstalk between
adipocytes and tumor cells in vivo, independently of dietary contributions, is a major gap in …