The development of therapeutic approaches for the induction of robust, long-lasting and
antigen-specific immune tolerance remains an important unmet clinical need for the …

The treatment of multiple sclerosis (MS) has changed over the last 20 years. All
immunotherapeutic drugs target relapsing remitting MS (RRMS) and it still remains a …

Background Although the cytokine IL-31 has been implicated in inflammatory and lymphoma-
associated itch, the cellular basis for its pruritic action is yet unclear. Objective We sought to …

Experimental autoimmune encephalomyelitis (EAE) is the most commonly used
experimental model for the human inflammatory demyelinating disease, multiple sclerosis …

Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) which involves a complex interaction between immune system and neural …

The main function of the immune system in health is to protect the host from infection by
microbes and parasites. Because immune responses to nonself bear the risk of unleashing …

Since the discovery of interleukin-10 (IL-10) in the 1980s, a large body of work has led to its
recognition as a pleiotropic immunomodulatory cytokine that affects both the innate and …

Substantial advances have elucidated some of the central mechanisms underlying the
inflammation, demyelination, and neurodegeneration that occur in multiple sclerosis …

Autoimmune diseases, with the exception of rheumatoid arthritis and autoimmune thyroiditis,
are individually rare, but together they affect approximately 5 percent of the population in …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …