Post-translational modifications: regulators of neurodegenerative proteinopathies

R Gupta, M Sahu, D Srivastava, S Tiwari… - Ageing research …, 2021 - Elsevier
One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

Therapeutic implications of phosphorylation-and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration

N Khakha, H Khan, A Kaur, TG Singh - Pharmacological Reports, 2023 - Springer
Neurodegeneration is a condition of the central nervous system (CNS) characterized by loss
of neural structures and function. The most common neurodegenerative disorders (NDDs) …

Neuroprotective potency of mangiferin against 3-nitropropionic acid induced Huntington's disease-like symptoms in rats: possible antioxidant and anti-inflammatory …

PT Lum, M Sekar, LJ Seow, MF Shaikh… - Frontiers in …, 2023 - frontiersin.org
Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of
adult life, followed by a gradual occurrence of psychiatric disturbances, cognitive and motor …

[HTML][HTML] Neuroprotective effect of α-mangostin in ameliorating propionic acid-induced experimental model of autism in Wistar rats

A Tiwari, R Khera, S Rahi, S Mehan, HA Makeen… - Brain Sciences, 2021 - mdpi.com
Several studies have documented the role of hyper-activation of extracellular signal-
regulated kinases (ERK) in Autism pathogenesis. Alpha-mangostin (AMG) is a …

Protective effect of natural products against Huntington's disease: An overview of scientific evidence and understanding their mechanism of action

PT Lum, M Sekar, SH Gan, SR Bonam… - ACS chemical …, 2021 - ACS Publications
Huntington's disease (HD), a neurodegenerative disease, normally starts in the prime of
adult life, followed by a gradual occurrence of characteristic psychiatric disturbances and …

Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats

RK Yadav, S Mehan, R Sahu, S Kumar… - Human & …, 2022 - journals.sagepub.com
Methylmercury (MeHg) is a neurotoxin that induces neurotoxicity and cell death in neurons.
MeHg increases oligodendrocyte death, glial cell activation, and motor neuron …

[HTML][HTML] Nrf2/HO-1 signaling stimulation through acetyl-11-keto-beta-boswellic acid (AKBA) provides neuroprotection in ethidium bromide-induced experimental …

S Upadhayay, S Mehan, A Prajapati, P Sethi, M Suri… - Genes, 2022 - mdpi.com
Multiple sclerosis (MS) is a severe immune-mediated neurological disease characterized by
neuroinflammation, demyelination, and axonal degeneration in the central nervous system …

Guggulsterone ameliorates ethidium bromide-induced experimental model of multiple sclerosis via restoration of behavioral, molecular, neurochemical and …

N Kumar, N Sharma, R Khera, R Gupta… - Metabolic brain disease, 2021 - Springer
Multiple Sclerosis (MS) is a progressive neurodegenerative disease with clinical signs of
neuroinflammation and the central nervous system's demyelination. Numerous studies have …

[HTML][HTML] Guggulsterone mediated JAK/STAT and PPAR-gamma modulation prevents neurobehavioral and neurochemical abnormalities in propionic acid-induced …

R Khera, S Mehan, S Bhalla, S Kumar, A Alshammari… - Molecules, 2022 - mdpi.com
Autism spectrum disorder is a neurodevelopmental disorder marked by repetitive behaviour,
challenges in verbal and non-verbal communication, poor socio-emotional health, and …

Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid …

S Rahi, R Gupta, A Sharma… - Human & Experimental …, 2021 - journals.sagepub.com
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disease characterized
by cognitive and sensorimotor impairment. Numerous research findings have consistently …