Pathogenesis and treatment of primary aldosteronism
MC Zennaro, S Boulkroun… - Nature Reviews …, 2020 - nature.com
Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …
Genetic spectrum and clinical correlates of somatic mutations in aldosterone-producing adenoma
FL Fernandes-Rosa, TA Williams, A Riester… - …, 2014 - Am Heart Assoc
Primary aldosteronism is the most common form of secondary hypertension. Somatic
mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone …
mutations in KCNJ5, ATP1A1, ATP2B3, and CACNA1D have been described in aldosterone …
Development of monoclonal antibodies against human CYP11B1 and CYP11B2
CE Gomez-Sanchez, X Qi, C Velarde-Miranda… - Molecular and cellular …, 2014 - Elsevier
The final enzymes in the biosynthesis of aldosterone and cortisol are by the cytochrome
P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the …
P450 CYP11B2 and CYP11B1, respectively. The enzymes are 93% homologous at the …
Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause
Most aldosterone-producing adenomas (APAs) have gain-of-function somatic mutations of
ion channels or transporters. However, their frequency in aldosterone-producing cell …
ion channels or transporters. However, their frequency in aldosterone-producing cell …
Genetic, cellular, and molecular heterogeneity in adrenals with aldosterone-producing adenoma
K De Sousa, S Boulkroun, S Baron, K Nanba… - …, 2020 - Am Heart Assoc
Aldosterone-producing adenoma (APA) cause primary aldosteronism—the most frequent
form of secondary hypertension. Somatic mutations in genes coding for ion channels and …
form of secondary hypertension. Somatic mutations in genes coding for ion channels and …
Primary aldosteronism: changing definitions and new concepts of physiology and pathophysiology both inside and outside the kidney
M Stowasser, RD Gordon - Physiological reviews, 2016 - journals.physiology.org
In the 60 years that have passed since the discovery of the mineralocorticoid hormone
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …
aldosterone, much has been learned about its synthesis (both adrenal and extra-adrenal) …
Testosterone lab testing and initiation in the United Kingdom and the United States, 2000 to 2011
JB Layton, D Li, CR Meier, JL Sharpless… - The Journal of …, 2014 - academic.oup.com
Context: The human adrenal zona fasciculata (ZF) and zona reticularis (ZR) are responsible
for the production of cortisol and 19-carbon steroids (often called adrenal androgens) …
for the production of cortisol and 19-carbon steroids (often called adrenal androgens) …
WNT/β-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production
A Berthon, C Drelon, B Ragazzon… - Human molecular …, 2014 - academic.oup.com
Primary aldosteronism (PA) is the main cause of secondary hypertension, resulting from
adrenal aldosterone-producing adenomas (APA) or bilateral hyperplasia. Here, we show …
adrenal aldosterone-producing adenomas (APA) or bilateral hyperplasia. Here, we show …
[HTML][HTML] Progression to adrenocortical tumorigenesis in mice and humans through insulin-like growth factor 2 and β-catenin
JH Heaton, MA Wood, AC Kim, LO Lima… - The American journal of …, 2012 - Elsevier
Dysregulation of the WNT and insulin-like growth factor 2 (IGF2) signaling pathways has
been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC) …
been implicated in sporadic and syndromic forms of adrenocortical carcinoma (ACC) …