Stem cell-based therapy for human diseases

DM Hoang, PT Pham, TQ Bach, ATL Ngo… - Signal transduction and …, 2022 - nature.com
Recent advancements in stem cell technology open a new door for patients suffering from
diseases and disorders that have yet to be treated. Stem cell-based therapy, including …

Coronavirus disease 2019 (COVID-19): current status and future perspectives

H Li, SM Liu, XH Yu, SL Tang, CK Tang - International journal of …, 2020 - Elsevier
ABSTRACT Coronavirus disease 2019 (COVID-19) originated in the city of Wuhan, Hubei
Province, Central China, and has spread quickly to 72 countries to date. COVID-19 is …

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

Matrix metalloproteinases as therapeutic targets for idiopathic pulmonary fibrosis

VJ Craig, L Zhang, JS Hagood… - American journal of …, 2015 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a restrictive lung disease that is associated with high
morbidity and mortality. Current medical therapies are not fully effective at limiting mortality …

Human mesenchymal stem cells (MSCs) for treatment towards immune-and inflammation-mediated diseases: review of current clinical trials

LT Wang, CH Ting, ML Yen, KJ Liu, HK Sytwu… - Journal of biomedical …, 2016 - Springer
Human mesenchymal stem cells (MSCs) are multilineage somatic progenitor/stem cells that
have been shown to possess immunomodulatory properties in recent years. Initially met with …

Mesenchymal stem cells: mechanisms of inflammation

NG Singer, AI Caplan - Annual Review of Pathology …, 2011 - annualreviews.org
In adults, human mesenchymal stem cells (hMSCs) are found in vivo at low frequency and
are defined by their capacity to differentiate into bone, cartilage, and adipose tissue …

[HTML][HTML] Mesenchymal stem cells from the Wharton's jelly of the human umbilical cord: biological properties and therapeutic potential

L Marino, MA Castaldi, R Rosamilio, E Ragni… - Int J stem …, 2019 - synapse.koreamed.org
Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high
differentiative potential, an immuno-privileged status and easy access for collection, which …

Allogeneic human mesenchymal stem cells in patients with idiopathic pulmonary fibrosis via intravenous delivery (AETHER): a phase I safety clinical trial

MK Glassberg, J Minkiewicz, RL Toonkel, ES Simonet… - Chest, 2017 - Elsevier
Background Despite Food and Drug Administration approval of 2 new drugs for idiopathic
pulmonary fibrosis (IPF), curative therapies remain elusive and mortality remains high …

Rationale for the clinical use of adipose-derived mesenchymal stem cells for COVID-19 patients

CJ Rogers, RJ Harman, BA Bunnell… - Journal of translational …, 2020 - Springer
In late 2019, a novel coronavirus (SARS-CoV-2) emerged in Wuhan, capital city of Hubei
province in China. Cases of SARS-CoV-2 infection quickly grew by several thousand per …

Lung extracellular matrix and fibroblast function

ES White - Annals of the American Thoracic Society, 2015 - atsjournals.org
Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides
physical support to tissues and is essential for normal organ function. In the lung, ECM plays …