Delay induced Hopf bifurcation and its control in a fractional p53 protein oscillator model
N Liu, H Yang, L Yang - Physica D: Nonlinear Phenomena, 2024 - Elsevier
The p53 protein is essential for cancer prevention. Research on p53 mathematical models is
popular since its oscillatory dynamics were observed. However, there is little research on …
popular since its oscillatory dynamics were observed. However, there is little research on …
[HTML][HTML] Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells
This study evaluated ethosomes as a novel nanodelivery system for nutlin-3a, a known
MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility …
MDM2 inhibitor and activator of the p53 pathway, to improve nutlin-3a's poor solubility …
Robust p53 recovery using chattering free sliding mode control and a gain-scheduled modified Utkin observer
Abstract p53 protein plays an essential role in protecting the genomic integrity of mammalian
cells. A drastic decrease in the amount of p53 protein has been observed in cancerous cells …
cells. A drastic decrease in the amount of p53 protein has been observed in cancerous cells …
System‐based strategies for p53 recovery
The authors have proposed a systems theory‐based novel drug design approach for the
p53 pathway. The pathway is taken as a dynamic system represented by ordinary differential …
p53 pathway. The pathway is taken as a dynamic system represented by ordinary differential …
[HTML][HTML] Mathematical modeling of E6-p53 interactions in cervical cancer
Background: Cervical cancer is the third most common cancer in women throughout the
world. The human papillomavirus (HPV) E6 viral protein plays an essential role in …
world. The human papillomavirus (HPV) E6 viral protein plays an essential role in …
Effect of Pharmacodynamical Interaction between Nutlin-3a and Aspirin in the Activation of P53
Background and objective p53, an anti-tumour protein, is significantly inactivated in most
tumours. A small molecule of nutlin-3a is used to activate its function by repressing (Mouse …
tumours. A small molecule of nutlin-3a is used to activate its function by repressing (Mouse …
Chronotherapy for the p53 system under DNA damage response
JF Jiao, HC Chang, RQ Wang - Biological Rhythm Research, 2022 - Taylor & Francis
ABSTRACT p53 is a signaling molecule that orchestrates smart responses to diverse stimuli
and employs temporal dynamics for the selective activation of downstream target genes and …
and employs temporal dynamics for the selective activation of downstream target genes and …
[HTML][HTML] Dynamic behavior of the p53-Mdm2 core module under the action of drug Nutlin and dual delays
J Yang, F Yan, H Liu - Mathematical Biosciences and Engineering, 2021 - aimspress.com
Nutlin is a family of p53-targeting drugs. It is able to bind to Mdm2, thereby accelerate the
accumulation of p53 that is a prominent tumor suppressor. An integrated module of the …
accumulation of p53 that is a prominent tumor suppressor. An integrated module of the …
State feedback based intervention design in Wnt and cell cycle network
Recent studies have shown a strong link between the cell cycle and the canonical version of
Wnt pathway. Based on these findings it can be safely speculated that Wnt pathway plays an …
Wnt pathway. Based on these findings it can be safely speculated that Wnt pathway plays an …
[PDF][PDF] Control Oriented Dosage Design for p53 Revival
MR Azam - 2020 - dev.cust.edu.pk
In the last few decades, cancer has become one of the leading causes of death in the
human race. A significant loss of the p53 protein, an anti-tumor agent, is observed in early …
human race. A significant loss of the p53 protein, an anti-tumor agent, is observed in early …