Tendon and ligament healing and current approaches to tendon and ligament regeneration
Ligament and tendon injuries are common problems in orthopedics. There is a need for
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …
Tendon tissue engineering: An overview of biologics to promote tendon healing and repair
Tendons are dense connective tissues with a hierarchical polarized structure that respond to
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …
and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion …
Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases
CC Deng, YF Hu, DH Zhu, Q Cheng, JJ Gu… - Nature …, 2021 - nature.com
Fibrotic skin disease represents a major global healthcare burden, characterized by
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts …
Tendon development and musculoskeletal assembly: emerging roles for the extracellular matrix
Tendons and ligaments are extracellular matrix (ECM)-rich structures that interconnect
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …
muscles and bones. Recent work has shown how tendon fibroblasts (tenocytes) interact with …
Tendon mechanobiology: Current knowledge and future research opportunities
Tendons mainly function as load‐bearing tissues in the muscloskeletal system; transmitting
loads from muscle to bone. Tendons are dynamic structures that respond to the magnitude …
loads from muscle to bone. Tendons are dynamic structures that respond to the magnitude …
Mohawk promotes the tenogenesis of mesenchymal stem cells through activation of the TGFβ signaling pathway
Abstract The transcription factor Mohawk (Mkx) is expressed in develo** tendons and is
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …
an important regulator of tenogenic differentiation. However, the exact roles of Mkx in …
[HTML][HTML] Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration
Y Shao, XB Wang, JJ Zhang, ML Li, SS Wu… - Nature …, 2020 - nature.com
The earthworm is particularly fascinating to biologists because of its strong regenerative
capacity. However, many aspects of its regeneration in nature remain elusive. Here we …
capacity. However, many aspects of its regeneration in nature remain elusive. Here we …
In vitro innovation of tendon tissue engineering strategies
Tendinopathy is the term used to refer to tendon disorders. Spontaneous adult tendon
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …
healing results in scar tissue formation and fibrosis with suboptimal biomechanical …
Stem cell technology for tendon regeneration: current status, challenges, and future research directions
PPY Lui - Stem cells and cloning: advances and applications, 2015 - Taylor & Francis
Tendon injuries are a common cause of physical disability. They present a clinical challenge
to orthopedic surgeons because injured tendons respond poorly to current treatments …
to orthopedic surgeons because injured tendons respond poorly to current treatments …
Heparin functionalization increases retention of TGF-β2 and GDF5 on biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering
The tendon/ligament-to-bone transition (enthesis) is a highly specialized interphase tissue
with structural gradients of extracellular matrix composition, collagen molecule alignment …
with structural gradients of extracellular matrix composition, collagen molecule alignment …