Clinical trials of stem cell therapy for cerebral ischemic stroke
M Kawabori, H Shichinohe, S Kuroda… - International Journal of …, 2020 - mdpi.com
Despite recent developments in innovative treatment strategies, stroke remains one of the
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …
Cell death mechanisms in stroke and novel molecular and cellular treatment options
E Sekerdag, I Solaroglu… - Current …, 2018 - ingentaconnect.com
As a result of ischemia or hemorrhage, blood supply to neurons is disrupted which
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …
subsequently promotes a cascade of pathophysiological responses resulting in cell loss …
[HTML][HTML] Stem cell therapy for abrogating stroke-induced neuroinflammation and relevant secondary cell death mechanisms
Ischemic stroke is a leading cause of death worldwide. A key secondary cell death
mechanism mediating neurological damage following the initial episode of ischemic stroke …
mechanism mediating neurological damage following the initial episode of ischemic stroke …
Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2)
Background Human neural stem cell implantation may offer improved recovery from stroke.
We investigated the feasibility of intracerebral implantation of the allogeneic human neural …
We investigated the feasibility of intracerebral implantation of the allogeneic human neural …
Mozobil®(Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration
E De Clercq - Antiviral Chemistry and Chemotherapy, 2019 - journals.sagepub.com
AMD3100 (plerixafor, Mozobil®) was first identified as an anti-HIV agent specifically active
against the T4-lymphotropic HIV strains, as it selectively blocked the CXCR4 receptor …
against the T4-lymphotropic HIV strains, as it selectively blocked the CXCR4 receptor …
CD34 positive cells as endothelial progenitor cells in biology and medicine
CD34 is a cell surface antigen expressed in numerous stem/progenitor cells including
hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known …
hematopoietic stem cells (HSCs) and endothelial progenitor cells (EPCs), which are known …
Intravenous bone marrow stem cell grafts preferentially migrate to spleen and abrogate chronic inflammation in stroke
Background and Purpose—Adult stem cell therapy is an experimental stroke treatment.
Here, we assessed homing and anti-inflammatory effects of bone marrow stromal cells …
Here, we assessed homing and anti-inflammatory effects of bone marrow stromal cells …
A phase 2 randomized, sham-controlled trial of internal carotid artery infusion of autologous bone marrow–derived ALD-401 cells in patients with recent stable …
Background: Ischemic stroke has no approved treatments to enhance recovery. ALD-401 is
an enriched population of aldehyde dehydrogenase-bright stem cells, capable of reducing …
an enriched population of aldehyde dehydrogenase-bright stem cells, capable of reducing …
Concise review: stem cell therapy for stroke patients: are we there yet?
CV Borlongan - Stem Cells Translational Medicine, 2019 - academic.oup.com
Four decades of preclinical research demonstrating survival, functional integration, and
behavioral effects of transplanted stem cells in experimental stroke models have provided …
behavioral effects of transplanted stem cells in experimental stroke models have provided …
Repair mechanisms of the neurovascular unit after ischemic stroke with a focus on VEGF
The functional neural circuits are partially repaired after an ischemic stroke in the central
nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial …
nervous system (CNS). In the CNS, neurovascular units, including neurons, endothelial …