Changing landscape of alcohol‐associated liver disease in younger individuals, women, and ethnic minorities

JP Arab, W Dunn, G Im, AK Singal - Liver International, 2024‏ - Wiley Online Library
Alcohol use is the most important determinant of the development of alcohol‐associated
liver disease (ALD) and of predicting long‐term outcomes in those with established liver …

Evolution of liver transplantation indications: expanding horizons

S Battistella, M Grasso, E Catanzaro, F D'Arcangelo… - Medicina, 2024‏ - mdpi.com
Liver transplantation (LT) has significantly transformed the prognosis of patients with end-
stage liver disease and hepatocellular carcinoma (HCC). The traditional epidemiology of …

Hepatoprotective potential of four fruit extracts rich in different structural flavonoids against alcohol-induced liver injury via gut microbiota-liver axis

Y Chen, H Ma, J Liang, C Sun, D Wang, K Chen… - Food Chemistry, 2024‏ - Elsevier
Alcoholic liver injury (ALI) accounts for a major share of the global burden of non-viral liver
disease. In the absence of specialized medications, research on using fruit flavonoids as a …

Alcohol-associated liver disease increases the risk of muscle loss and mortality in patients with cirrhosis

T Hanai, K Nishimura, S Unome, T Miwa… - Journal of …, 2024‏ - Springer
Background Rapid skeletal muscle loss adversely affects the clinical outcomes of liver
cirrhosis. However, the relationships between the annual changes in skeletal muscle area …

[HTML][HTML] Disulfiram

M Stokes, P Patel, S Abdijadid - StatPearls [Internet], 2024‏ - ncbi.nlm.nih.gov
Objectives: Identify the Food and Drug Administration-approved indications for disulfiram
therapy. Identify the mechanism of action of disulfiram corresponding to its indicated use …

At the Crossroads of Health and Disease: Consequences of Fat in the Liver

M Dukewich, L Yuan, NA Terrault - Annual Review of Physiology, 2025‏ - annualreviews.org
The liver plays a central role in regulating lipid and glucose metabolism, particularly in
transitioning between energy storage and provision in fed and fasting states. Loss of …

[HTML][HTML] New biomarkers in liver fibrosis: a pass through the quicksand?

M Tagliaferro, M Marino, V Basile, K Pocino… - Journal of Personalized …, 2024‏ - mdpi.com
Chronic liver diseases (CLD) stem from various causes and lead to a gradual progression
that ultimately may result in fibrosis and eventually cirrhosis. This process is typically …

Flavonoids from Rhododendron nivale Hook. f ameliorate alcohol-associated liver disease via activating the PPARα signaling pathway

X Guo, C Liu, Z Dong, G Luo, Q Li, M Huang - Phytomedicine, 2024‏ - Elsevier
Background Flavonoids are increasingly recognized for their potent antioxidant properties
and potential therapeutic roles in the management of alcohol-associated liver disease …

Alcohol-related liver disease (ALD): current perspectives on pathogenesis, therapeutic strategies, and animal models

X Hong, S Huang, H Jiang, Q Ma, J Qiu… - Frontiers in …, 2024‏ - frontiersin.org
Alcohol-related liver disease (ALD) is a major cause of morbidity and mortality worldwide. It
encompasses conditions such as fatty liver, alcoholic hepatitis, chronic hepatitis with liver …

PNPLA3 rs738409, environmental factors and liver-related mortality in the US population

E Vilar-Gomez, S Gawrieh, R Vuppalanchi, C Kettler… - Journal of …, 2024‏ - Elsevier
Background & Aims Little is known about the interplay between patatin-like phospholipase
domain-containing protein 3 (PNPLA3 rs738409 C> G), environmental factors, and the risk …