Steroidogenesis, the processes by which cholesterol is converted to steroid hormones,
involves transport proteins, enzymes, redox partners and cofactors. Most steroidogenic …

Mammalian cytochromes P450 are an important class of enzymes involved in the
biotransformation of many endo-and exogenous compounds. Cytochrome P450 isoforms …

The crystal structure of the complex between the heme-and FMN-binding domains of
bacterial cytochrome P450BM-3, a prototype for the complex between eukaryotic …

Four distinct suggestions have been made to explain the mechanism of the cytochrome b5-
imposed positive modifier action of the cytochrome P450 monooxygenase reaction. The first …

Microsomal cytochrome P450s participate in xenobiotic detoxification, procarcinogen
activation, and steroid hormone synthesis. The first structure of a mammalian microsomal …

Polymer‐based nanodiscs are valuable tools in biomedical research that can offer a
detergent‐free solubilization of membrane proteins maintaining their native lipid …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

Cytochrome P450 enzymes catalyze the degradation of drugs and xenobiotics, but also
catalyze a wide variety of biosynthetic processes, including most steps in steroidogenesis …

The xenobiotic metabolizing cytochromes P450 (P450s) are among the most versatile
biological catalysts known, but knowledge of the structural basis for their broad substrate …

Cytochromes P450 form a very large superfamily of proteins which metabolize substrates
from steroids to fatty acids to drugs and are found in organisms from protists to mammals …