Identifying the interactions established by a protein of interest can be a critical step in
understanding its function. This is especially true when an unknown protein of interest is …

Proteins are the key players in many cellular processes. Their composition, trafficking, and
interactions underlie the dynamic processes of life. Furthermore, diseases are frequently …

Cellular processes often depend on stable physical associations between proteins. Despite
recent progress, knowledge of the composition of human protein complexes remains limited …

The carboxy-terminal domain (CTD) of the RNA polymerase II (RNAP II) subunit POLR2A is
a platform for modifications specifying the recruitment of factors that regulate transcription …

Map** protein–protein interactions for chromatin-associated proteins remains
challenging. Here we explore the use of BioID, a proximity biotinylation approach in which a …

The pentaspan membrane glycoprotein CD133 marks lineage-specific cancer progenitor
cells and is associated with poor prognosis in a number of tumor types. Despite its utility as a …

Protein-protein interactions (PPIs) and multi-protein complexes perform central roles in the
cellular systems of all living organisms. In humans, disruptions of the normal patterns of PPIs …

Our group recently described recurrent somatic mutations of the miRNA processing gene
DICER1 in non‐epithelial ovarian cancer. Mutations appeared to be clustered around each …

Neurogenesis requires the concerted action of numerous genes that are regulated at
multiple levels. However, how different layers of gene regulation are coordinated to promote …

In most solid tumors, the Hippo pathway is inactivated through poorly understood
mechanisms that result in the activation of the transcriptional regulators, YAP and TAZ. Here …