Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities

E Lubos, J Loscalzo, DE Handy - 2011 - liebertpub.com
Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …

Flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders

M Ayaz, A Sadiq, M Junaid, F Ullah, M Ovais… - Frontiers in aging …, 2019 - frontiersin.org
Modern research has revealed that dietary consumption of flavonoids and flavonoids-rich
foods significantly improve cognitive capabilities, inhibit or delay the senescence process …

Small molecule modulators of K eap1‐N rf2‐ARE pathway as potential preventive and therapeutic agents

S Magesh, Y Chen, L Hu - Medicinal research reviews, 2012 - Wiley Online Library
K elch‐like ECH‐associated protein 1 (K eap1)‐nuclear factor erythroid 2‐related factor 2 (N
rf2)‐antioxidant response elements (ARE) pathway represents one of the most important …

Effects of flavonoids and other polyphenols on inflammation

R González, I Ballester, R López-Posadas… - Critical reviews in …, 2011 - Taylor & Francis
Flavonoids are a family of polyphenolic compounds which are widespread in nature
(vegetables) and are consumed as part of the human diet in significant amounts. There are …

Multi-targeted therapy of cancer by genistein

S Banerjee, Y Li, Z Wang, FH Sarkar - Cancer letters, 2008 - Elsevier
Soy isoflavones have been identified as dietary components having an important role in
reducing the incidence of breast and prostate cancers in Asian countries. Genistein, the …

Beyond the cholesterol-lowering effect of soy protein: a review of the effects of dietary soy and its constituents on risk factors for cardiovascular disease

DD Ramdath, EMT Padhi, S Sarfaraz, S Renwick… - Nutrients, 2017 - mdpi.com
The hypocholesterolemic effect of soy is well-documented and this has led to the regulatory
approval of a health claim relating soy protein to a reduced risk of cardiovascular disease …

Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease

RJ Williams, JPE Spencer - Free Radical Biology and Medicine, 2012 - Elsevier
There is increasing evidence that the consumption of flavonoid-rich foods can beneficially
influence normal cognitive function. In addition, a growing number of flavonoids have been …

Flavonoids: modulators of brain function?

JPE Spencer - British journal of nutrition, 2008 - cambridge.org
Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert
beneficial effects on the central nervous system by protecting neurons against stress …

Asteraceae species with most prominent bioactivity and their potential applications: A review

SMF Bessada, JCM Barreira, MBPP Oliveira - Industrial Crops and …, 2015 - Elsevier
Oxidative stress has a relevant part in the etiology of several diseases and metabolic
disorders, being reasonable to expect that antioxidant compounds might have beneficial …

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity

Y Zhang, Y **ang - Biochemical Journal, 2016 - portlandpress.com
The consensus cis-regulatory AP-1 (activator protein-1)-like AREs (antioxidant-response
elements) and/or EpREs (electrophile-response elements) allow for differential recruitment …