Chirality, an inherent characteristic observed throughout nature, plays a pivotal role across a
wide range of scales, from subatomic to galactic, and holds significance in myriad scientific …

Protein misfolding diseases (PMDs) in humans are characterized by the deposition of
protein aggregates in tissues, including Alzheimer's disease, Parkinson's disease, type 2 …

The mechanical properties of biomaterials are dictated by the interactions and
conformations of their building blocks, typically proteins. Although the macroscopic behavior …

Second-order nonlinear processes like Sum-Frequency Generation (SFG) are essentially
defined in the electric dipolar approximation. However, when dealing with the SFG …

Amyloid fibrils are protein aggregates formed by protein assembly through cross β
structures. Inhibition of amyloid fibril formation may contribute to therapy against amyloid …

This year marks the 60th anniversary of the observation of optical second-harmonic
generation (SHG) from a calcite surface by Terhune, Marker, and Savage, 1 and the first …

Protein misfolding and amyloid formation are implicated in the protein dysfunction, but the
underlying mechanism remains to be clarified due to the lack of effective tools for detecting …

Sum-frequency nonlinear spectroscopy is a powerful tool in investigating physical and
chemical properties at gas/liquid, gas/solid, liquid/liquid and liquid/solid interfaces. Fermi …

(1) Background: Viral hepatitis C (HCV) and viral hepatitis B (HBV) are common co-
infections in people living with HIV (PLWH). All PLWH should be vaccinated against HBV …

Local H-bonding interactions are crucial for proteins to undergo various structural transitions
and form different secondary structures. However, identifying slight distinctions in the local H …