Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tip** point”. Some examples are mass extinctions …

A molecular description of functional modules in the cell is the focus of many high-
throughput studies in the postgenomic era. A large portion of biomolecular interactions in …

Waddington's epigenetic landscape is probably the most famous and most powerful
metaphor in developmental biology. Cells, represented by balls, roll downhill through a …

Non-alcoholic fatty liver disease (NAFLD) has emerged as a public health problem of
epidemic proportions worldwide. Accumulating clinical and epidemiological evidence …

Computational modeling and the theory of nonlinear dynamical systems allow one to not
simply describe the events of the cell cycle, but also to understand why these events occur …

One does not often look to analytic cubism for insights into the control of the cell cycle, but
Pablo Picasso beautifully encapsulated the fundamentals when he said that “every act of …

The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the
model organism S. cerevisiae. Research performed during the past decade has significantly …

The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3
ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of …

The mitosis-to-interphase transition involves dramatic cellular reorganization from a state
that supports chromosome segregation to a state that complies with all functions of an …

The anaphase-promoting complex or cyclosome (APC/C) is a ubiquitin ligase that
polyubiquitinates specific substrates at precise times in the cell cycle, thereby triggering the …