Protein–protein interactions or protein complexes are integral in nearly all cellular
processes, ranging from metabolism to structure. Elucidating both individual protein …

Inflammasomes are intracellular protein complexes that drive the activation of inflammatory
caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have …

The zona pellucida (ZP) is a specialized extracellular coat that surrounds the plasma
membrane of mammalian eggs. Its presence is essential for successful completion of …

Curli are functional amyloid fibres that constitute the major protein component of the
extracellular matrix in pellicle biofilms formed by Bacteroidetes and Proteobacteria …

C-reactive protein (CRP) concentrations rise in response to tissue injury or infection.
Circulating pentameric CRP (pCRP) localizes to damaged tissue where it leads to …

The NLRP3 inflammasome is an important regulator of inflammation and immunity. It is a
multimolecular platform formed within cells that facilitates the activation of proinflammatory …

Autophagosomes are double‐membrane vesicles generated during autophagy. Biogenesis
of the autophagosome requires membrane acquisition from intracellular compartments, the …

Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) is commonly used
to obtain high resolution separation of complex mixtures of proteins. The method initially …

Most adaptive immune responses require the activation of specific T cells through the T cell
antigen receptor (TCR)–CD3 complex. Here we show that cholesterol sulfate (CS), a …

TIP47 (tail-interacting protein of 47 kD) was characterized as a cargo selection device for
mannose 6-phosphate receptors (MPRs), directing their transport from endosomes to the …