Bacterial genomes encode the biosynthetic potential to produce hundreds of thousands of
complex molecules with diverse applications, from medicine to agriculture and materials …

The ability of bacteria to respond to changes in their environment is critical to their survival,
allowing them to withstand stress, form complex communities, and induce virulence …

Genetic programs function to integrate environmental sensors, implement signal processing
algorithms and control expression dynamics. These programs consist of integrated genetic …

Bacterial genes associated with a single trait are often grouped in a contiguous unit of the
genome known as a gene cluster. It is difficult to genetically manipulate many gene clusters …

Gene circuits are dynamical systems that regulate cellular behaviors, often using protein
signals as inputs and outputs. Here we have developed an optogenetic'function …

Virulence factors generally enhance a pathogen's fitness and thereby foster transmission.
However, most studies of pathogen fitness have been performed by averaging the …

Setting the standard in synthetic biology | Nature Biotechnology Skip to main content Thank you
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The type III secretion system (T3SS) exports proteins from the cytoplasm, through both the
inner and outer membranes, to the external environment. Here, a system is constructed to …

Gene regulation networks contain recurring circuit patterns called network motifs. One of the
most common network motif is the incoherent type 1 feed‐forward loop (I1‐FFL), in which an …

Salmonella invade non-phagocytic cells by inducing massive actin rearrangements,
resulting in membrane ruffle formation and phagocytosis of the bacteria. This process is …